Antibiotics Drive Microbial Imbalance and Vitiligo Development in Mice.
Antibiotics Drive Microbial Imbalance and Vitiligo Development in Mice.
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DOI：
10.1016/j.jid.2019.08.435
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发表时间：
2020-03
影响因子：
6.5
通讯作者：
Le Poole, I. Caroline
中科院分区：
文献类型：
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作者：
Dellacecca, Emilia R.;Cosgrove, Cormac;Mukhatayev, Zhussipbek;Akhtar, Suhail;Engelhard, Victor H.;Rademaker, Alfred W.;Knight, Katherine L.;Le Poole, I. Caroline
白癜风受环境诱因的影响。我们研究了微生物群在FH小鼠中的作用，在FH小鼠中，色素脱失是由酪氨酸酶反应性T细胞介导的。小鼠接受口服抗生素，并接受色素脱失监测。通过16S rRNA分析对粪便和皮肤样品中的微生物群进行了研究。由此产生的T细胞分布被评估。在未经治疗的小鼠中，色素损失没有扩大到皮毛，而氨苄西林组的小鼠在30周时大约有三分之一的色素脱色。与较少依赖干扰素-γ的自身免疫模型相反，氨苄西林治疗而不是新霉素治疗与疾病加速和粪便中细菌减少有关。组织和血清中修改过的细胞因子模式表明了一种超越肠道的反应。氨苄西林诱导的色素脱失伴随着肠道而不是皮肤的生物失调，并减少了两个部位的T细胞。新霉素可引起肠道T细胞的重新分布和皮肤Tregs的聚集。这种治疗刺激了以类杆菌为主的粪便细菌种群。当肠道中以假单胞菌为主时，多样性减少的现象尤为突出，尤其是在氨苄西林治疗后。根据目前与微生物组和免疫系统相关的概念，我们预测饮食措施可能会促进皮肤健康，推迟白癜风的发病。
Vitiligo is impacted by environmental triggers. We studied the contribution of the microbiome in FH mice, where depigmentation is mediated by tyrosinase-reactive T cells. Mice received oral antibiotics and were monitored for depigmentation. The microbiome was studied in fecal and skin samples by 16S rRNA analysis. Resulting T-cell distributions were evaluated. In untreated mice, pigment loss did not expand to the pelage, whereas mice in the ampicillin group were about 1/3 depigmented at 30 weeks. Contrary to models of autoimmunity that are less dependent on IFN-γ, ampicillin but not neomycin treatment correlated with accelerated disease and reduced bacteria in fecal pellets. Modified cytokine patterns in tissue and serum suggest a response that transcends the gut. Ampicillin-induced depigmentation was accompanied by gut but not skin dysbiosis, and reduced T cells in both sites. Neomycin induced a redistribution of gut T cells and accumulation of skin Tregs. This treatment spurred a Bacteroides-dominated population of fecal bacteria. Reduced diversity is prominent especially after ampicillin treatment, when the gut is dominated by Pseudomonas species. In line with current concepts relating the microbiome and the immune system, we predict that dietary measures might promote skin health and delay vitiligo onset.
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影响因子：
16.6
作者：
Duvallet C;Gibbons SM;Gurry T;Irizarry RA;Alm EJ
通讯作者：
Alm EJ
影响因子：
30.8
作者：
Jin, Ying;Andersen, Genevieve;Yorgov, Daniel;Ferrara, Tracey M.;Ben, Songtao;Brownson, Kelly M.;Holland, Paulene J.;Birlea, Stanca A.;Siebert, Janet;Hartmann, Anke;Lienert, Anne;van Geel, Nanja;Lambert, Jo;Luiten, Rosalie M.;Wolkerstorfer, Albert;van der Veen, J. P. Wietze;Bennett, Dorothy C.;Taieb, Alain;Ezzedine, Khaled;Kemp, E. Helen;Gawkrodger, David J.;Weetman, Anthony P.;Koks, Sulev;Prans, Ele;Kingo, Kulli;Karelson, Maire;Wallace, Margaret R.;McCormack, Wayne T.;Overbeck, Andreas;Moretti, Silvia;Colucci, Roberta;Picardo, Mauro;Silverberg, Nanette B.;Olsson, Mats;Valle, Yan;Korobko, Igor;Boehm, Markus;Lim, Henry W.;Hamzavi, Iltefat;Zhou, Li;Mi, Qing-Sheng;Fain, Pamela R.;Santorico, Stephanie A.;Spritz, Richard A.
通讯作者：
Spritz, Richard A.
影响因子：
2.4
作者：
Grimes, Pearl E.;Nashawati, Rama
通讯作者：
Nashawati, Rama
影响因子：
6.5
作者：
Denman, Cecele J.;McCracken, James;Le Poole, I. Caroline
通讯作者：
Le Poole, I. Caroline
DOI：
10.4049/jimmunol.0902778
发表时间：
2010-02-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Gregg RK;Nichols L;Chen Y;Lu B;Engelhard VH
通讯作者：
Engelhard VH