High blood pressure before and during early pregnancy is associated with an increased risk of gestational diabetes mellitus.
High blood pressure before and during early pregnancy is associated with an increased risk of gestational diabetes mellitus.
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怀孕前后的高血压与妊娠糖尿病的风险增加有关。
DOI：
10.2337/dc08-1193
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发表时间：
2008-12
期刊：
影响因子：
16.2
通讯作者：
Ferrara, Assiamira
中科院分区：
文献类型：
--
作者：
Hedderson, Monique M.;Ferrara, Assiamira
目的——虽然既往患有妊娠糖尿病 (GDM) 的女性在产后几年内更有可能表现出代谢综合征的特征，包括高血压，但尚不清楚这些成分在怀孕前是否也存在。我们在一项巢式病例对照研究中研究了妊娠前和妊娠早期（<20 周）期间测量的血压 (BP) 与 GDM 风险之间的关系。研究设计和方法——病例 (n = 381) 和对照 (n = 942) 受试者选自 1996 年至 1998 年间分娩的妇女队列，并在妊娠 24 至 28 周之间筛查 GDM。 GDM 由国家糖尿病数据组标准定义。血压和协变量数据是通过审查医疗记录获得的。根据美国心脏协会推荐的妊娠期外血压水平对女性进行分类：<120/80 mmHg（正常）、120-139/80-89 mmHg（高血压前期）、≥140 和/或 ≥90 mmHg 或使用抗高血压药物（高血压）。结果：妊娠早期，高血压前期女性患 GDM 的风险略有增加（比值比 [OR] 1.56 [95% CI 1.16–2.10]），在调整年龄、种族/民族、孕周血压、BMI 和体重后，与血压正常的女性相比，高血压女性患 GDM 的风险增加两倍（2.04 [1.14–3.65]）。平价。在怀孕前测量血压水平的女性子集中也发现了类似的结果（高血压前期为 1.44 [0.95–2.19]，高血压为 2.01 [1.01–3.99]）。结论——临床医生应该意识到，患有高血压的女性可能需要早期筛查或干预来预防 GDM。
OBJECTIVE—While women with prior gestational diabetes mellitus (GDM) are more likely to display features of the metabolic syndrome, including hypertension, in the years after delivery, it is unclear whether these components are also present before pregnancy. We examined the relationship between blood pressure (BP) measured before and during early pregnancy (<20 weeks) and the risk of GDM in a nested case-control study. RESEARCH DESIGN AND METHODS—Case (n = 381) and control (n = 942) subjects were selected from a cohort of women delivering between 1996 and 1998 and screened for GDM between 24 and 28 weeks’ gestation. GDM was defined by the National Diabetes Data Group criteria. BP and covariates data were obtained by review of the medical records. Women were categorized according to BP levels recommended by the American Heart Association outside of pregnancy: <120/80 mmHg (normal), 120–139/80–89 mmHg (prehypertension), and ≥140 and/or ≥90 mmHg or use of antihypertensive medications (hypertension). RESULTS—During early pregnancy, women with prehypertension had a small increased risk of GDM (odds ratio [OR] 1.56 [95% CI 1.16–2.10]), and women with hypertension had a twofold increased risk of GDM (2.04 [1.14–3.65]) compared with women with normal BP after adjusting for age, race/ethnicity, gestational week of BP, BMI, and parity. Similar results were seen among the subset of women with BP levels measured before pregnancy (1.44 [0.95–2.19] for prehypertension and 2.01 [1.01–3.99] for hypertension). CONCLUSIONS—Clinicians should be aware that women presenting with hypertension may warrant early screening or intervention to prevent GDM.
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影响因子：
158.5
作者：
Knowler, WC;Barrett-Connor, E;Nathan, DM
通讯作者：
Nathan, DM
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Albareda, M;Caballero, A;Corcoy, R
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Corcoy, R
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Stamatelopoulos, SF
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Damm, P
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作者：
Hermida, RC;Ayala, DE;Iglesias, M
通讯作者：
Iglesias, M