On the fabric of the human body.
On the fabric of the human body.
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在人体的织物上。
作者：
Zankhana Raval;Douglas Losordo
随着 1543 年《De Humani Corporis Fabrica》的出版，安德烈亚斯·维萨里 (Andreas Vesalius) 带来了自盖伦时代以来解剖学理解上最伟大的进步，纠正了主要的误解，例如大血管起源于肝脏的观念。解剖学思维的这一演变花了近 1500 年的时间才发生。
近 500 年后，解剖学研究同样活跃且充满进化变化，这既令人感到谦卑，又令人振奋。在本期《循环》中，Kajstura 及其同事1 明确提出了心脏是一种终末分化器官的教条，这一概念在 40 年前就已提出，从而完全重新调整了我们对健康和患病心脏中细胞稳态的理解。
文章见第 1869 页
1973年，芝加哥大学的拉多万·扎克（Radovan Zak2）明确指出：“成人心脏的扩大只能通过其组成肌细胞的扩大来实现。哺乳动物的心室肌细胞的分裂在心脏损伤后不会被激活。”这一结论与 Linzbach3 1960 年的工作基本一致；然而，在早期的综合组织学分析中，有人建议在某些情况下心肌纤维的数量可能会增加。
Anversa 实验室于 1980 年开始提出心肌细胞增殖的可能性，4 到 1992 年，该小组开始记录实验模型 5-8 和人类中心肌细胞复制以响应生理应激和心肌损伤的明确证据。 9,10 这些早期工作包括诸如“控制心肌细胞增殖的因素的认识可能为受损和丢失的心肌细胞的再生提供一种新方法”等大胆的陈述。 几十年来，这种现象被认为是不可能的。”尽管一些人认识到这些观察的力量和影响，但普费弗夫妇呼吁开放思想……
With the publication of De Humani Corporis Fabrica in 1543, Andreas Vesalius bestowed some of the greatest advancements of anatomic understanding since the time of Galen, correcting major misconceptions, eg, the notion that the great vessels originated in the liver. It took nearly 1500 years for this evolution in anatomic thinking to transpire.
It is simultaneously humbling and invigorating to note that nearly 500 years later the study of anatomy is just as lively and full of evolutionary change. In this issue of Circulation , Kajstura and colleagues1 definitively dispatch the dogma of the heart as a terminally differentiated organ, a concept formulated a mere 40 years earlier, and in so doing completely recalibrate our understanding of cellular homeostasis in the healthy and diseased heart.
Article see p 1869
In 1973, Radovan Zak2 of the University of Chicago stated unequivocally, “The adult heart enlarges only by enlargement of its component muscle cells. Division of ventricular muscle cells in mammals is not activated after cardiac injury.” This conclusion was largely consistent with work by Linzbach3 in 1960; however, in this earlier comprehensive histological analysis, there was a suggestion that under certain circumstances the number of cardiac muscle fibers might increase.
The Anversa laboratory began suggesting the possibility of cardiomyocyte proliferation in 1980,4 and by 1992, the group began to document clear evidence for replication of cardiac muscle cells in response to physiological stress and myocardial injury in both experimental models5–8 and humans.9,10 These early works included such bold statements as “the recognition of factors controlling myocyte proliferation may provide a new approach for regeneration of damaged and lost myocardium, a phenomenon considered impossible for several decades.” Although some recognized the power and implications of these observations, the Pfeffers' call for open-mindedness …
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人类的终末期心力衰竭与心室肌细胞中增殖细胞核抗原和核有丝分裂的诱导有关。
影响因子：
20.1
作者：
Quaini,F;Cigola,E;Lagrasta,C;Saccani,G;Quaini,E;Rossi,C;Olivetti,G;Anversa,P
通讯作者：
Anversa,P
影响因子：
24
作者：
G. Olivetti;M. Melissari;Tiziana Balbi;F. Quaini;E. Sonnenblick;P. Anversa
通讯作者：
G. Olivetti;M. Melissari;Tiziana Balbi;F. Quaini;E. Sonnenblick;P. Anversa
出生后成熟和衰老过程中心脏中的肌细胞肥大和增生。
DOI：
--
发表时间：
1992
期刊：
Acta paediatrica (Oslo, Norway : 1992). Supplement
影响因子：
--
作者：
Anversa,P;Capasso,JM;Olivetti,G;Sonnenblick,EH
通讯作者：
Sonnenblick,EH
心肌细胞肥大和增生有助于贫血引起的大鼠心脏肥大的心室壁重塑。
DOI：
--
发表时间：
1992
期刊：
The American journal of pathology
影响因子：
--
作者：
Olivetti,G;Quaini,F;Lagrasta,C;Ricci,R;Tiberti,G;Capasso,JM;Anversa,P
通讯作者：
Anversa,P
DOI：
10.1042/cs20120641
发表时间：
2013-08
期刊：
Clinical science (London, England : 1979)
影响因子：
--
作者：
Weil BR;Canty JM Jr
通讯作者：
Canty JM Jr