Curcumin in Retinal Diseases: A Comprehensive Review from Bench to Bedside.

Curcumin in Retinal Diseases: A Comprehensive Review from Bench to Bedside.
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视网膜疾病中的姜黄素:从长凳到床边的全面评论。

DOI:
10.3390/ijms23073557
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发表时间:
2022-03-24
影响因子:
5.6
通讯作者:
Romano MR
Romano MR
中科院分区:
生物学2区
文献类型:
--
作者:
Allegrini D;Raimondi R;Borgia A;Sorrentino T;Montesano G;Tsoutsanis P;Cancian G;Verma Y;De Rosa FP;Romano MR

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最新的基础科学证据使人们对姜黄素在治疗视网膜疾病中可能发挥的作用越来越感兴趣。姜黄素已被证明能够调节基因转录,减少神经节细胞凋亡,下调血管内皮生长因子,调节血糖水平,减少血管功能障碍。到目前为止,姜黄素的使用一直受到生物利用度差的限制;为了克服这个问题,已经使用了不同类型的载体。最近的多项研究揭示了使用姜黄素治疗不同视网膜状况的疗效。本综述的目的是全面综述和讨论姜黄素在视网膜疾病中从长凳到床边的作用。
Recent evidence in basic science is leading to a growing interest in the possible role of curcumin in treating retinal diseases. Curcumin has been demonstrated to be able to modulate gene transcription and reduce ganglion cell apoptosis, downgrade VEGF, modulate glucose levels and decrease vascular dysfunction. So far, the use of curcumin has been limited by poor bioavailability; to overcome this issue, different types of carriers have been used. Multiple recent studies disclosed the efficacy of using curcumin in treating different retinal conditions. The aim of this review is to comprehensively review and discuss the role of curcumin in retinal diseases from bench to bedside.
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