Increased Expression of CCN2 in the Red Flashing Light-Induced Myopia in Guinea Pigs
Increased Expression of CCN2 in the Red Flashing Light-Induced Myopia in Guinea Pigs
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CCN2 在红光闪烁引起的豚鼠近视中表达增加
DOI：
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发表时间：
2013
影响因子：
--
通讯作者：
Hongling Yang
中科院分区：
文献类型：
--
作者：
Hong Wang;K. Zhuang;Lei Gao;Linna Zhang;Hongling Yang
视觉环境在近视的发生中起着重要作用。我们之前表明，不同的闪光会对近视的眼睛生长和发展产生不同的影响。据报道，CCN2 可以调节各种细胞功能和生物过程。然而，CCN2信号是否参与红光闪烁引起的近视仍不清楚。在本研究中，我们在体内研究了红色闪光照射对眼睛屈光和眼轴长度的影响，然后评估了它们对巩膜组织中CCN2和TGF-β表达的影响。我们的数据显示，暴露在红色闪烁光下的眼睛变得更加近视，眼轴显着增加，屈光度降低。 CCN2 和 TGF-β 以及 p38 MAPK 和 PI3K 在暴露于红色闪光的巩膜组织中高度表达。研究发现 CCN2 和 TGF-β 在体内具有相同的基因表达谱。总之，我们的研究结果发现CCN2信号通路在体内红色闪光诱发的近视中发挥重要作用。此外，我们的研究为实验性近视研究建立了有用的动物模型。
Visual environment plays an important role in the occurrence of myopia. We previously showed that the different flashing lights could result in distinct effects on the ocular growth and development of myopia. CCN2 has been reported to regulate various cellular functions and biological processes. However, whether CCN2 signaling was involved in the red flashing light-induced myopia still remains unknown. In the present study, we investigated the effects of the red flashing lights exposure on the refraction and axial length of the eyes in vivo and then evaluated their effects on the expression of CCN2 and TGF-β in sclera tissues. Our data showed that the eyes exposed to the red flashing light became more myopic with a significant increase of the axial length and decrease of the refraction. Both CCN2 and TGF-β, as well as p38 MAPK and PI3K, were highly expressed in the sclera tissues exposed to the red flashing light. Both CCN2 and TGF-β were found to have the same gene expression profile in vivo. In conclusion, our findings found that CCN2 signaling pathway plays an important role in the red flashing light-induced myopia in vivo. Moreover, our study establishes a useful animal model for experimental myopia research.
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DOI：
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发表时间：
2010
期刊：
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影响因子：
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作者：
C. Frey
通讯作者：
C. Frey
影响因子：
4.4
作者：
J. Rada;D. Nickla;D. Troilo
通讯作者：
J. Rada;D. Nickla;D. Troilo
DOI：
10.4331/wjbc.v3.i3.41
发表时间：
2012-03-26
期刊：
World journal of biological chemistry
影响因子：
--
作者：
Guo, Xia;Chen, Shi-You
通讯作者：
Chen, Shi-You
影响因子：
3.3
作者：
IGARASHI, A;OKOCHI, H;GROTENDORST, GR
通讯作者：
GROTENDORST, GR