Paradigm Shift in Dendritic Cell-Based Immunotherapy: From in vitro Generated Monocyte-Derived DCs to Naturally Circulating DC Subsets.
Paradigm Shift in Dendritic Cell-Based Immunotherapy: From in vitro Generated Monocyte-Derived DCs to Naturally Circulating DC Subsets.
复制标题
DOI：
10.3389/fimmu.2014.00165
复制
发表时间：
2014
影响因子：
7.3
通讯作者：
De Vries IJ
中科院分区：
文献类型：
--
作者：
Wimmers F;Schreibelt G;Sköld AE;Figdor CG;De Vries IJ
基于树突状细胞（DC）的免疫疗法利用患者的免疫系统来对抗遍布全身的肿瘤病变。这使其成为患有转移性黑色素瘤的患者的重要治疗选择，转移性黑色素瘤通常对化疗具有抗性。然而，传统的细胞疫苗接种方法，基于单核细胞衍生的DC（moDC），尽管不断优化的各种疫苗接种参数，仅实现适度的反应率。此外，moDC的产生需要广泛的离体培养，这可能会妨碍疫苗的免疫原性。因此，最近的研究集中在利用原代DC的疫苗上。虽然在血液中罕见，但这些天然循环的DC可以容易地分离和活化，从而避免了漫长的离体培养期。第一批临床试验不仅显示了生存率的提高，而且还诱导了多样化的抗癌免疫反应。即将到来的治疗范例旨在将几种主要DC亚群包括在单一疫苗中，因为临床前研究确定了各种抗原呈递细胞之间的协同效应。
Dendritic cell (DC)-based immunotherapy employs the patients’ immune system to fight neoplastic lesions spread over the entire body. This makes it an important therapy option for patients suffering from metastatic melanoma, which is often resistant to chemotherapy. However, conventional cellular vaccination approaches, based on monocyte-derived DCs (moDCs), only achieved modest response rates despite continued optimization of various vaccination parameters. In addition, the generation of moDCs requires extensive ex vivo culturing conceivably hampering the immunogenicity of the vaccine. Recent studies, thus, focused on vaccines that make use of primary DCs. Though rare in the blood, these naturally circulating DCs can be readily isolated and activated thereby circumventing lengthy ex vivo culture periods. The first clinical trials not only showed increased survival rates but also the induction of diversified anti-cancer immune responses. Upcoming treatment paradigms aim to include several primary DC subsets in a single vaccine as pre-clinical studies identified synergistic effects between various antigen-presenting cells.
登录
查看更多内容
影响因子：
30.5
作者：
Cella, M;Facchetti, F;Colonna, M
通讯作者：
Colonna, M
影响因子：
30.5
作者：
D'Amico, G;Frascaroli, G;Mantovani, A
通讯作者：
Mantovani, A
影响因子：
4.4
作者：
Bioley, Gilles;Jandus, Camilla;Romero, Pedro
通讯作者：
Romero, Pedro
影响因子：
45.3
作者：
Balch, Charles M.;Gershenwald, Jeffrey E.;Sondak, Vernon K.
通讯作者：
Sondak, Vernon K.
影响因子：
11.5
作者：
Aarntzen, Erik H. J. G.;Srinivas, Mangala;de Vries, I. Jolanda M.
通讯作者：
de Vries, I. Jolanda M.