Ventromedial Prefrontal Cortex Is Critical for Helping Others Who Are Suffering.
Ventromedial Prefrontal Cortex Is Critical for Helping Others Who Are Suffering.
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DOI：
10.3389/fneur.2018.00288
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发表时间：
2018
影响因子：
3.4
通讯作者：
Tranel D
中科院分区：
文献类型：
--
作者：
Beadle JN;Paradiso S;Tranel D
在临床病例研究中，有报道称，腹内侧额叶皮质(VmPFC)受损的神经科患者在日常生活中对他人的同理心降低。然而，vmPFC受损患者的共情行为还没有被实验测量，以应对引发共情的事件。这一点很重要，因为表征vmPFC受损患者的共情行为较低的程度将允许开发有针对性的干预措施，以提高患者的社交技能，并反过来将帮助家庭成员更好地了解他们的障碍，以便他们能够提供适当的支持。我们首次在vmPFC受损的神经科患者中使用生态上有效的共情诱导来诱导共情，并实时测量他们的共情情绪反应和行为。将8名vmPFC局灶性受损的神经科患者与人口统计学上匹配的脑损伤患者和健康对照参与者进行比较。与对照组参与者相比，vmPFC受损的患者在同理心状况下给予遭受痛苦的人(邦联成员)的钱更少。这提供了第一个直接的实验证据，证明vmPFC对于对遭受痛苦的个人的移情行为至关重要。
Neurological patients with damage to the ventromedial prefrontal cortex (vmPFC) are reported to display reduced empathy toward others in their daily lives in clinical case studies. However, the empathic behavior of patients with damage to the vmPFC has not been measured experimentally in response to an empathy-eliciting event. This is important because characterizing the degree to which patients with damage to the vmPFC have lower empathic behavior will allow for the development of targeted interventions to improve patients’ social skills and in turn will help family members to better understand their impairments so they can provide appropriate supports. For the first time, we induced empathy using an ecologically-valid empathy induction in neurological patients with damage to the vmPFC and measured their empathic emotional responses and behavior in real time. Eight neurological patients with focal damage to the vmPFC were compared to demographically-matched brain-damaged and healthy comparison participants. Patients with damage to the vmPFC gave less money in the empathy condition to a person who was suffering (a confederate) than comparison participants. This provides the first direct experimental evidence that the vmPFC is critical for empathic behavior toward individuals who are suffering.
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DOI：
10.1017/s1355617704103123
发表时间：
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影响因子：
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