Increased programmed death-1 molecule expression in cytomegalovirus disease and acute graft-versus-host disease after allogeneic hematopoietic cell transplantation.
Increased programmed death-1 molecule expression in cytomegalovirus disease and acute graft-versus-host disease after allogeneic hematopoietic cell transplantation.
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DOI：
10.1016/j.bbmt.2009.03.022
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发表时间：
2009-07
期刊：
影响因子：
--
通讯作者：
Zaia JA
中科院分区：
文献类型：
--
作者：
Gallez-Hawkins GM;Thao L;Palmer J;Dagis A;Li X;Franck AE;Tegtmeier B;Lacey SF;Diamond DJ;Forman SJ;Zaia JA
为了研究PD-1在同种异体HCT后CMV感染和疾病中的作用，前瞻性随访了206例受试者对CMV的免疫应答，并根据CMV结局将其分配至3组。回顾性分析了移植后第40、90、120、150、180和360天收集的冻存CD 4和CD 8 + T细胞中的PD-1表达。将患有CMV疾病的HCT受者（n=14）与患有长期CMV感染但没有CMV疾病的受者（感染的中位持续时间：3个月; n=14）以及类似的无CMV感染的移植对照（n=22）进行比较。CMV疾病组具有PD-1的平均荧光强度（MFI），其在研究的所有时间点在CD 4+（p< 0.05）和CD 8+（p<0.05）淋巴细胞中显著更高。此外，PD-1在患有严重急性移植物抗宿主病（aGVHD）的患者中显著增加，包括无病毒血症组。数据表明，即使在不存在CMV感染的情况下，PD-1也由aGVHD诱导。在严重aGVHD期间PD-1表达的增强和CMV再激活的发生，可以解释aGVHD作为CMV疾病的危险因素的已知作用。
To study the role of PD-1 in CMV infection and disease after allogeneic HCT, 206 subjects were followed prospectively for immune response to CMV and assigned to three groups based on CMV outcome. They were analyzed retrospectively for PD-1 expression in cryopreserved CD4 and CD8+ T-cells collected at days 40, 90, 120, 150, 180, and 360 post-transplant. HCT recipients with CMV disease (n=14), were compared to recipients with prolonged CMV infection but no CMV disease (median duration of infection: 3 months; n=14) and to similarly transplanted controls with no CMV infection (n=22). The CMV Disease Group had a mean fluorescence intensity (MFI) of PD-1 which was significantly higher in CD4+ (p< 0.05) and CD8+ (p<0.05) lymphocytes at all time points studied. In addition, PD-1 was significantly increased in those with severe acute graft vs host disease (aGVHD), including the No-Viremia group. The data suggest that PD-1 is induced by aGVHD even in absence of CMV infection. This enhancement of PD-1 expression during severe aGVHD and occuring with CMV reactivation, could explain the known role of aGVHD as a risk factor for CMV disease.
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