Cardiovascular health and risk of hospitalization with COVID-19: A Mendelian Randomization study.
Cardiovascular health and risk of hospitalization with COVID-19: A Mendelian Randomization study.
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DOI：
10.1177/20480040211059374
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发表时间：
2021-01
影响因子：
1.6
通讯作者：
Chowienczyk P
中科院分区：
文献类型：
--
作者：
Cecelja M;Lewis CM;Shah AM;Chowienczyk P
新冠肺炎的易感性和严重程度与心血管疾病的危险因素和存在相关。我们进行了两样本孟德尔随机抽样，以确定血压(BP)、体重指数(BMI)、2型糖尿病(T2 DM)和冠状动脉疾病(CAD)的存在是否与严重新冠肺炎的出现存在因果关系。变异暴露工具变量相关性是根据最近发表的全基因组关联和荟萃分析研究(GWAS)确定的，该研究具有公开的概要水平的GWAS数据。不同结果的关联来自最近一项对实验室确认的新冠肺炎诊断的GWA荟萃分析，其严重程度根据住院/死亡需要而确定。我们还检验了使用暴露作为严重新冠肺炎导致心血管疾病的诊断的反向因果关系。我们没有发现心血管危险因素/疾病与严重的新冠肺炎(与人口对照相比)之间存在因果关系的证据，也没有发现反向因果关系的证据。特别是对BP和T2 DM的因果优势比(OR，经逆方差加权回归)接近于1[相对较窄的可信区间，P = 0.927，接近于1]。在观察性研究中报道的心血管危险因素/疾病与新冠肺炎住院的相关性可能是由于社会经济因素和/或那些影响住院指征的残余混淆所致。
Susceptibility to and severity of COVID-19 is associated with risk factors for and presence of cardiovascular disease. We performed a 2-sample Mendelian randomization to determine whether blood pressure (BP), body mass index (BMI), presence of type 2 diabetes (T2DM) and coronary artery disease (CAD) are causally related to presentation with severe COVID-19. Variant-exposure instrumental variable associations were determined from most recently published genome-wide association and meta-analysis studies (GWAS) with publicly available summary-level GWAS data. Variant-outcome associations were obtained from a recent GWAS meta-analysis of laboratory confirmed diagnosis of COVID-19 with severity determined according to need for hospitalization/death. We also examined reverse causality using exposure as diagnosis of severe COVID-19 causing cardiovascular disease. We found no evidence for a causal association of cardiovascular risk factors/disease with severe COVID-19 (compared to population controls), nor evidence of reverse causality. Causal odds ratios (OR, by inverse variance weighted regression) for BP (OR for COVID-19 diagnosis 1.00 [95% confidence interval (CI): 0.99–1.01, P = 0.604] per genetically predicted increase in BP) and T2DM (OR for COVID-19 diagnosis to that of genetically predicted T2DM 1.02 [95% CI: 0.9–1.05, P = 0.927], in particular, were close to unity with relatively narrow confidence intervals. The association between cardiovascular risk factors/disease with that of hospitalization with COVID-19 reported in observational studies could be due to residual confounding by socioeconomic factors and /or those that influence the indication for hospital admission.
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影响因子：
3.5
作者：
Pulit SL;Stoneman C;Morris AP;Wood AR;Glastonbury CA;Tyrrell J;Yengo L;Ferreira T;Marouli E;Ji Y;Yang J;Jones S;Beaumont R;Croteau-Chonka DC;Winkler TW;GIANT Consortium;Hattersley AT;Loos RJF;Hirschhorn JN;Visscher PM;Frayling TM;Yaghootkar H;Lindgren CM
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Mahajan A;Taliun D;Thurner M;Robertson NR;Torres JM;Rayner NW;Payne AJ;Steinthorsdottir V;Scott RA;Grarup N;Cook JP;Schmidt EM;Wuttke M;Sarnowski C;Mägi R;Nano J;Gieger C;Trompet S;Lecoeur C;Preuss MH;Prins BP;Guo X;Bielak LF;Below JE;Bowden DW;Chambers JC;Kim YJ;Ng MCY;Petty LE;Sim X;Zhang W;Bennett AJ;Bork-Jensen J;Brummett CM;Canouil M;Ec Kardt KU;Fischer K;Kardia SLR;Kronenberg F;Läll K;Liu CT;Locke AE;Luan J;Ntalla I;Nylander V;Schönherr S;Schurmann C;Yengo L;Bottinger EP;Brandslund I;Christensen C;Dedoussis G;Florez JC;Ford I;Franco OH;Frayling TM;Giedraitis V;Hackinger S;Hattersley AT;Herder C;Ikram MA;Ingelsson M;Jørgensen ME;Jørgensen T;Kriebel J;Kuusisto J;Ligthart S;Lindgren CM;Linneberg A;Lyssenko V;Mamakou V;Meitinger T;Mohlke KL;Morris AD;Nadkarni G;Pankow JS;Peters A;Sattar N;Stančáková A;Strauch K;Taylor KD;Thorand B;Thorleifsson G;Thorsteinsdottir U;Tuomilehto J;Witte DR;Dupuis J;Peyser PA;Zeggini E;Loos RJF;Froguel P;Ingelsson E;Lind L;Groop L;Laakso M;Collins FS;Jukema JW;Palmer CNA;Grallert H;Metspalu A;Dehghan A;Köttgen A;Abecasis GR;Meigs JB;Rotter JI;Marchini J;Pedersen O;Hansen T;Langenberg C;Wareham NJ;Stefansson K;Gloyn AL;Morris AP;Boehnke M;McCarthy MI
通讯作者：
McCarthy MI
影响因子：
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作者：
Wu C;Chen X;Shu J;Lee CT
通讯作者：
Lee CT
影响因子：
2.9
作者：
Collard D;Nurmohamed NS;Kaiser Y;Reeskamp LF;Dormans T;Moeniralam H;Simsek S;Douma R;Eerens A;Reidinga AC;Elbers PWG;Beudel M;Vogt L;Stroes ESG;van den Born BH
通讯作者：
van den Born BH
对冠状动脉疾病进行基于 1,000 个基因组的全面全基因组关联荟萃分析。
影响因子：
30.8
作者：
Nikpay M;Goel A;Won HH;Hall LM;Willenborg C;Kanoni S;Saleheen D;Kyriakou T;Nelson CP;Hopewell JC;Webb TR;Zeng L;Dehghan A;Alver M;Armasu SM;Auro K;Bjonnes A;Chasman DI;Chen S;Ford I;Franceschini N;Gieger C;Grace C;Gustafsson S;Huang J;Hwang SJ;Kim YK;Kleber ME;Lau KW;Lu X;Lu Y;Lyytikäinen LP;Mihailov E;Morrison AC;Pervjakova N;Qu L;Rose LM;Salfati E;Saxena R;Scholz M;Smith AV;Tikkanen E;Uitterlinden A;Yang X;Zhang W;Zhao W;de Andrade M;de Vries PS;van Zuydam NR;Anand SS;Bertram L;Beutner F;Dedoussis G;Frossard P;Gauguier D;Goodall AH;Gottesman O;Haber M;Han BG;Huang J;Jalilzadeh S;Kessler T;König IR;Lannfelt L;Lieb W;Lind L;Lindgren CM;Lokki ML;Magnusson PK;Mallick NH;Mehra N;Meitinger T;Memon FU;Morris AP;Nieminen MS;Pedersen NL;Peters A;Rallidis LS;Rasheed A;Samuel M;Shah SH;Sinisalo J;Stirrups KE;Trompet S;Wang L;Zaman KS;Ardissino D;Boerwinkle E;Borecki IB;Bottinger EP;Buring JE;Chambers JC;Collins R;Cupples LA;Danesh J;Demuth I;Elosua R;Epstein SE;Esko T;Feitosa MF;Franco OH;Franzosi MG;Granger CB;Gu D;Gudnason V;Hall AS;Hamsten A;Harris TB;Hazen SL;Hengstenberg C;Hofman A;Ingelsson E;Iribarren C;Jukema JW;Karhunen PJ;Kim BJ;Kooner JS;Kullo IJ;Lehtimäki T;Loos RJF;Melander O;Metspalu A;März W;Palmer CN;Perola M;Quertermous T;Rader DJ;Ridker PM;Ripatti S;Roberts R;Salomaa V;Sanghera DK;Schwartz SM;Seedorf U;Stewart AF;Stott DJ;Thiery J;Zalloua PA;O'Donnell CJ;Reilly MP;Assimes TL;Thompson JR;Erdmann J;Clarke R;Watkins H;Kathiresan S;McPherson R;Deloukas P;Schunkert H;Samani NJ;Farrall M
通讯作者：
Farrall M