Vitamin D and cardiovascular disease.
Vitamin D and cardiovascular disease.
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DOI：
10.3390/nu2040426
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发表时间：
2010-04
期刊：
影响因子：
5.9
通讯作者：
Martini LA
中科院分区：
文献类型：
--
作者：
Garcia VC;Martini LA
维生素D不足/缺乏症在世界各地的生命的各个阶段都有观察到。它已被定性为一个公共卫生问题，因为这种维生素的低浓度与几种慢性疾病的发病机制有关。一些研究表明，维生素D与心血管疾病有关，并提供了证据表明它在降低心血管疾病风险方面具有作用。它可能通过各种细胞中维生素D受体的存在参与基因表达的调节、血压的调节（通过肾素-血管紧张素系统）以及细胞生长和增殖（包括血管平滑肌细胞和心肌细胞）的调节。确定维生素D和这些疾病之间的正确机制和关系对于患者护理和医疗保健政策可能很重要。
Vitamin D insufficiency/deficiency has been observed worldwide at all stages of life. It has been characterized as a public health problem, since low concentrations of this vitamin have been linked to the pathogenesis of several chronic diseases. Several studies have suggested that vitamin D is involved in cardiovascular diseases and have provided evidence that it has a role in reducing cardiovascular disease risk. It may be involved in regulation of gene expression through the presence of vitamin D receptors in various cells, regulation of blood pressure (through renin-angiotensin system), and modulation of cell growth and proliferation including vascular smooth muscle cells and cardiomyocytes. Identifying correct mechanisms and relationships between vitamin D and such diseases could be important in relation to patient care and healthcare policies.
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影响因子：
7.1
作者：
Heaney, RP
通讯作者：
Heaney, RP
DOI：
10.1073/pnas.0611202104
发表时间：
2007-10-23
影响因子：
11.1
作者：
Bodyak, Natalya;Ayus, Juan Carlos;Kang, Peter M.
通讯作者：
Kang, Peter M.
DOI：
10.1111/j.1440-1681.1991.tb01637.x
发表时间：
1991-09-01
影响因子：
2.9
作者：
IMAOKA, M;MORIMOTO, S;OGIHARA, T
通讯作者：
OGIHARA, T
影响因子：
5.3
作者：
Kendrick, Jessica;Targher, Giovanni;Chonchol, Michel
通讯作者：
Chonchol, Michel
影响因子：
168.9
作者：
Lewington, S;Clarke, R;Collins, R
通讯作者：
Collins, R