Cortical and subcortical connections of V1 and V2 in early postnatal macaque monkeys.
Cortical and subcortical connections of V1 and V2 in early postnatal macaque monkeys.
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DOI：
10.1002/cne.22732
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发表时间：
2012-02-15
影响因子：
2.5
通讯作者：
Kaas, Jon H.
中科院分区：
文献类型：
--
作者：
Baldwin, Mary K. L.;Kaskan, Peter M.;Zhang, Bin;Chino, Yuzo M.;Kaas, Jon H.
在2 ~ 16周龄猕猴体内注射少量霍乱毒素亚单位B（CT B），观察到初级视区（V1）和次级视区（V2）的连接。将皮质压平并平行于表面切割，以显示注射部位、标记细胞的模式和细胞色素氧化酶（CO）染色的模式。从外侧膝状体核和枕到V1的投射在4周龄时出现，枕投射到V2的薄和厚CO条纹。注射到V1在4和8周龄的猴子标记的神经元V2，V3，中颞区（MT），背外侧区（DL）/V4。在V1和V2内，标记神经元密集地分布在注射部位周围，但在远离注射部位处形成斑块。注射到2周龄、4周龄和8周龄猴的V1、V3、DL/V4和MT中的V2标记神经元中。注射在薄条纹的V2优先标记的神经元在其他V2薄条纹和神经元在CO斑点区域的V1。在4周龄时，V2中可能的粗条纹注射标记了斑点周围的神经元。注射V2后，V1区标记神经元主要分布于皮层浅层，其他区域标记神经元分布于皮层深层。虽然这些功能的成人V1和V2连接早在出生后2周，标记的细胞在V1和V2变得更加局限于首选CO车厢后2周龄。
Connections of primary (V1) and secondary (V2) visual areas were revealed in macaque monkeys ranging in age from 2 to 16 weeks by injecting small amounts of cholera toxin subunit B (CTB). Cortex was flattened and cut parallel to the surface to reveal injection sites, patterns of labeled cells, and patterns of cytochrome oxidase (CO) staining. Projections from the lateral geniculate nucleus and pulvinar to V1 were present at 4 weeks of age, as were pulvinar projections to thin and thick CO stripes in V2. Injections into V1 in 4- and 8-week-old monkeys labeled neurons in V2, V3, middle temporal area (MT), and dorsolateral area (DL)/V4. Within V1 and V2, labeled neurons were densely distributed around the injection sites, but formed patches at distances away from injection sites. Injections into V2 labeled neurons in V1, V3, DL/V4, and MT of monkeys 2-, 4-, and 8-weeks of age. Injections in thin stripes of V2 preferentially labeled neurons in other V2 thin stripes and neurons in the CO blob regions of V1. A likely thick stripe injection in V2 at 4 weeks of age labeled neurons around blobs. Most labeled neurons in V1 were in superficial cortical layers after V2 injections, and in deep layers of other areas. Although these features of adult V1 and V2 connectivity were in place as early as 2 postnatal weeks, labeled cells in V1 and V2 became more restricted to preferred CO compartments after 2 weeks of age.
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