Temperature-dependent virus lifecycle choices may reveal and predict facets of the biology of opportunistic pathogenic bacteria.
Temperature-dependent virus lifecycle choices may reveal and predict facets of the biology of opportunistic pathogenic bacteria.
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DOI：
10.1038/s41598-018-27716-3
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发表时间：
2018-06-25
影响因子：
4.6
通讯作者：
Galyov EE
中科院分区：
文献类型：
--
作者：
Egilmez HI;Morozov AY;Clokie MRJ;Shan J;Letarov A;Galyov EE
类鼻疽病是由假鼻疽伯克霍尔德氏菌引起的一种严重疾病，可导致感染患者高达40%的死亡。在热带水和土壤中发现了这种病原体。最近的发现表明，细菌的数量可以通过一种新的噬菌体支系来调节，这种噬菌体在土壤和水中含量丰富。这些噬菌体以不同的方式感染它们的细菌宿主，导致高温下的裂解和低温下的裂解。因此，季节和每日温度的变化会导致噬菌体-细菌相互作用的开关。我们使用真实参数建立了数学模型，以探索在季节变化的环境条件下，随着时间的推移，噬菌体对稻田地表水中假鼻疽杆菌种群的影响。历史记录被用来提供泰国两个省的紫外线辐射水平和温度。这些模型预测，无噬菌体细菌数量的季节性变化与在“温暖潮湿”季节感染类鼻疽病的风险较高有关。我们发现，环境的丰富可能会导致细菌数量的不规则大幅度脉冲，这可能会显着增加感染疾病的可能性。我们的结果表明，这些噬菌体可能在整个季节调节假鼻疽菌群，这些数据可能有助于改善东南亚的类鼻疽病预防工作。
Melioidosis, a serious illness caused by Burkholderia pseudomallei, results in up to 40% fatality in infected patients. The pathogen is found in tropical water and soil. Recent findings demonstrated that bacterial numbers can be regulated by a novel clade of phages that are abundant in soil and water. These phages differentially infect their bacterial hosts causing lysis at high temperatures and lysogeny at lower temperatures. Thus seasonal and daily temperature variations would cause switches in phage-bacteria interactions. We developed mathematical models using realistic parameters to explore the impact of phages on B. pseudomallei populations in the surface water of rice fields over time and under seasonally changing environmental conditions. Historical records were used to provide UV radiation levels and temperature for two Thailand provinces. The models predict seasonal variation of phage-free bacterial numbers correlates with the higher risk of melioidosis acquisition during the “warm and wet” season. We find that enrichment of the environment may lead to irregular large amplitude pulses of bacterial numbers that could significantly increase the probability of disease acquisition. Our results suggest that the phages may regulate B. pseudomallei populations throughout the seasons, and these data can potentially help improve the melioidosis prevention efforts in Southeast Asia.
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影响因子：
5.2
作者：
Bryan D;El-Shibiny A;Hobbs Z;Porter J;Kutter EM
通讯作者：
Kutter EM
DOI：
10.1073/pnas.0600166103
发表时间：
2006-03-21
影响因子：
11.1
作者：
Jensen, MA;Faruque, SM;Levin, BR
通讯作者：
Levin, BR
影响因子：
1.9
作者：
Gourley, SA;Kuang, Y
通讯作者：
Kuang, Y
影响因子：
4.4
作者：
Iriarte, F. B.;Balogh, B.;Jones, J. B.
通讯作者：
Jones, J. B.
影响因子：
28.3
作者：
Limmathurotsakul, Direk;Golding, Nick;Hay, Simon I.
通讯作者：
Hay, Simon I.