A recommended numbering scheme for influenza A HA subtypes.
A recommended numbering scheme for influenza A HA subtypes.
复制标题
甲型亚型的推荐编号方案。
DOI：
10.1371/journal.pone.0112302
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Smith DJ
中科院分区：
文献类型：
--
作者：
Burke DF;Smith DJ
流感病毒亚型之间残基的比较越来越多地用于评估一种流行毒株的人畜共患潜力和跨亚型的比较研究。Nobusawa和他的同事先前对13种甲型流感血凝素（HA）序列亚型的n端切割位点进行了分析。我们将这一分析扩展到18种已知的流感亚型。由于HA长度的差异，我们纳入了来自H1和H5多个分支的菌株，以及具有高致病性和低致病性的H5和H7亚型菌株。对甲型流感HA已知结构的分析使我们能够使用基于成熟HA序列的编号系统定义在所有HA亚型中结构和功能相同的氨基酸。我们提供了一个氨基酸的等效列表，已知影响病毒的表型。
Comparisons of residues between sub-types of influenza virus is increasingly used to assess the zoonotic potential of a circulating strain and for comparative studies across subtypes. An analysis of N-terminal cleavage sites for thirteen subtypes of influenza A hemagglutinin (HA) sequences, has previously been described by Nobusawa and colleagues. We have expanded this analysis for the eighteen known subtypes of influenza. Due to differences in the length of HA, we have included strains from multiple clades of H1 and H5, as well as strains of H5 and H7 subtypes with both high and low pathogenicity. Analysis of known structures of influenza A HA enables us to define amino acids which are structurally and functionally equivalent across all HA subtypes using a numbering system based on the mature HA sequence. We provide a list of equivalences for amino acids which are known to affect the phenotype of the virus.
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影响因子：
6.7
作者：
Watanabe Y;Ibrahim MS;Ellakany HF;Kawashita N;Mizuike R;Hiramatsu H;Sriwilaijaroen N;Takagi T;Suzuki Y;Ikuta K
通讯作者：
Ikuta K
影响因子：
3.7
作者：
Chen LM;Blixt O;Stevens J;Lipatov AS;Davis CT;Collins BE;Cox NJ;Paulson JC;Donis RO
通讯作者：
Donis RO
影响因子：
88.1
作者：
Medina, Rafael A.;Garcia-Sastre, Adolfo
通讯作者：
Garcia-Sastre, Adolfo
影响因子：
64.8
作者：
Yamada, Shinya;Suzuki, Yasuo;Kawaoka, Yoshihiro
通讯作者：
Kawaoka, Yoshihiro
影响因子：
64.8
作者：
Imai, Masaki;Watanabe, Tokiko;Hatta, Masato;Das, Subash C.;Ozawa, Makoto;Shinya, Kyoko;Zhong, Gongxun;Hanson, Anthony;Katsura, Hiroaki;Watanabe, Shinji;Li, Chengjun;Kawakami, Eiryo;Yamada, Shinya;Kiso, Maki;Suzuki, Yasuo;Maher, Eileen A.;Neumann, Gabriele;Kawaoka, Yoshihiro
通讯作者：
Kawaoka, Yoshihiro