Characteristics associated with early- vs. later-onset adult diabetes: The CARDIA study.
Characteristics associated with early- vs. later-onset adult diabetes: The CARDIA study.
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DOI：
10.1016/j.diabres.2021.109144
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发表时间：
2021-12
影响因子：
5.1
通讯作者：
Spezia Faulkner M
中科院分区：
文献类型：
--
作者：
Cha E;Pasquel FJ;Yan F;Jacobs DR Jr;Dunbar SB;Umpierrez G;Choi Y;Shikany JM;Bancks MP;Reis JP;Spezia Faulkner M
研究了早期（< 40 岁）与晚发（≥ 40 岁）糖尿病患者的风险状况差异。采用巢式病例对照研究设计，使用年轻人冠状动脉风险发展 (CARDIA) 研究的 30 年纵向数据。调查数据（社会人口统计、家族史、医疗记录和生活方式行为）、肥胖相关指标（体重指数、体重）、血压和实验室数据（胰岛素、空腹血糖、2 小时血糖和血脂）用于检查早发性糖尿病与晚发性糖尿病患者的糖尿病进展模式。在 605 名参与者中，120 名属于早发组，485 名属于晚发组。早发组的先验饮食质量评分较低，但基线时不具有统计学意义；然而，在首次检测到糖尿病时，组间差异变得显着 (p=.026)。在早发组和晚发组中，体力活动强度评分从基线到糖尿病发生持续下降。早发组在基线时和首次发现糖尿病时表现出更多的血脂异常，并且从基线到发展为糖尿病时体重快速增加。强调对无症状年轻人进行生活方式改变和基于风险的糖尿病筛查对于早期发现和预防是必要的。
Differences in risk profiles for individuals with early- (< 40 years old) vs. later-onset (≥ 40 years old) diabetes were examined. A nested case-control study design using 30-year longitudinal data from the Coronary Artery Risk Development in Young Adults (CARDIA) study was used. Survey data (socio-demographics, family history, medical records, and lifestyle behaviors), obesity-related measures (body mass index, weight), blood pressure, and laboratory data (insulin, fasting glucose, 2-h glucose, and lipids) were used to examine progression patterns of diabetes development in those with early-onset vs. later-onset diabetes. Of 605 participants, 120 were in early-onset group while 485 were in later-onset group. Early-onset group had a lower A Priori Diet Quality Score, but not statistically significant at baseline; however, the between-group difference became significant at the time that diabetes was first detected (p=.026). The physical activity intensity score consistently decreased from baseline to the development of diabetes in both the early- and later-onset groups. Early-onset group showed more dyslipidemia at baseline and at the time that diabetes was first detected, and rapid weight gain from baseline to the development of diabetes. Emphases on lifestyle modification and risk-based diabetes screening in asymptomatic young adults are necessary for early detection and prevention.
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影响因子：
158.5
作者：
Knowler, WC;Barrett-Connor, E;Nathan, DM
通讯作者：
Nathan, DM
影响因子：
2
作者：
Chen, Chung-Yu;Pereira, Mark A.;Fabio, Anthony
通讯作者：
Fabio, Anthony
DOI：
10.1097/00008483-198911000-00003
发表时间：
1989-11-01
期刊：
Journal of cardiopulmonary rehabilitation
影响因子：
--
作者：
Jacobs, David R Jr;Hahn, Lorraine P;Sidney, Stephen
通讯作者：
Sidney, Stephen
影响因子：
158.5
作者：
Christakis, Nicholas A.;Fowler, James H.
通讯作者：
Fowler, James H.
影响因子：
16.2
作者：
Bancks, Michael P.;Ning, Hongyan;Wilkins, John T.
通讯作者：
Wilkins, John T.