The life and miracles of kinetochores.
The life and miracles of kinetochores.
复制标题
DOI：
10.1038/emboj.2009.173
复制
发表时间：
2009-09-02
期刊：
影响因子：
11.4
通讯作者：
Musacchio, Andrea
中科院分区：
文献类型：
--
作者：
Santaguida, Stefano;Musacchio, Andrea
Kinetochores are large protein assemblies built on chromosomal loci named centromeres. The main functions of kinetochores can be grouped under four modules. The first module, in the inner kinetochore, contributes a sturdy interface with centromeric chromatin. The second module, the outer kinetochore, contributes a microtubule-binding interface. The third module, the spindle assembly checkpoint, is a feedback control mechanism that monitors the state of kinetochore–microtubule attachment to control the progression of the cell cycle. The fourth module discerns correct from improper attachments, preventing the stabilization of the latter and allowing the selective stabilization of the former. In this review, we discuss how the molecular organization of the four modules allows a dynamic integration of kinetochore–microtubule attachment with the prevention of chromosome segregation errors and cell-cycle progression.
登录
查看更多内容
影响因子：
21.3
作者：
Bakhoum, Samuel F.;Thompson, Sarah L.;Manning, Amity L.;Compton, Duane A.
通讯作者：
Compton, Duane A.
影响因子：
4
作者：
Cimini, D;Moree, B;Salmon, ED
通讯作者：
Salmon, ED
影响因子：
3.3
作者：
Cohen, R. L.;Espelin, C. W.;Simons, K. T.
通讯作者：
Simons, K. T.
影响因子：
7.5
作者：
Black, Ben E.;Bassett, Emily A.
通讯作者：
Bassett, Emily A.
影响因子：
64.5
作者：
Ciferri, Claudio;Pasqualato, Sebastiano;Musacchio, Andrea
通讯作者：
Musacchio, Andrea