Adult-adult living donor liver transplantation
Adult-adult living donor liver transplantation
复制标题
成人-成人活体肝移植
DOI：
10.1016/j.gassur.2003.12.005
复制
发表时间：
2004
影响因子：
3.2
通讯作者：
M. Schwartz
中科院分区：
文献类型：
--
作者：
M. Makuuchi;Charles M. Miller;K. Olthoff;M. Schwartz
自1998年丹佛首次报道利用活体供者的右肝在成人身上成功移植后，这种手术迅速被许多移植中心采用，作为解决供体肝脏严重短缺的潜在解决方案。到2000年底，当国家卫生研究院举行关于成人-成人活体供体移植(AALDT)的协商一致会议时，已经发展了大量的文献，并确定了许多相关的技术和医学陷阱。2002年1月，当一名捐赠者在西奈山医院死亡时，手术的指数级扩张戏剧性地停止了。西奈山医院是美国最繁忙的AALDT中心。这导致了对右叶捐献固有风险的广泛重新评估。然而，推动这项有争议的技术发展的问题--可供移植的器官严重短缺--仍然存在。与2001年相比，2002年在美国进行的AALDT手术数量下降了50%，尽管对随之而来的风险有了更高的认识，但中心正在重新组织并以新的兴趣接近AALDT。2002年11月2日，由美国肝-胰腺-胆道协会和美国肝病研究协会联合主办的关于AALDT的最先进的研讨会在马萨诸塞州的波士顿举行。这篇文章包括在研讨会上关于AALDT的三个至关重要的主题的介绍。这些包括手术技术、候选对象的选择和肝再生方面的进展；每个主题都由该领域的专家认可。
After the first report from Denver in 1998 of a successful liver transplant in an adult using the right lobe from a living donor, the procedure was rapidly adopted by many transplant centers as a potential solution to the critical shortage of donor livers. By the end of 2000, when the National Institutes of Health held a Consensus Conference on Adult-Adult Living Donor Transplantation (AALDT), a substantial body of literature had already developed and many of the associated technical and medical pitfalls had been defined. The exponential expansion of the procedure came to a dramatic halt in January 2002 when the death of a donor occurred at Mount Sinai Hospital—the busiest AALDT center in the United States. This led to a widespread reassessment of the risks inherent in right lobe donation. Yet, the problem that drove the development of this controversial technique—the dire shortage of organs for transplantation—still persists. After a 50% drop in the number of AALDT procedures performed in the United States in 2002 compared with 2001, centers are regrouping and approaching AALDT with renewed interest, albeit with heightened awareness of the attendant risks. On November 2, 2002, a state-of-the-art symposium on AALDT was held in Boston, MA, under the combined auspices of the American Hepatico-Pancreato-Biliary Association and the American Association for the Study of Liver Diseases. This article comprises the presentations at the symposium on three subjects of critical importance concerning AALDT. These include advances in surgical technique, candidate selection, and hepatic regeneration; each subject is acknowledged by an expert in the field.
登录
查看更多内容
影响因子：
2.2
作者：
Debonera, F;Aldeguer, X;Olthoff, KM
通讯作者：
Olthoff, KM
DOI：
10.1002/lt.500050401
发表时间：
1999-07-01
期刊：
LIVER TRANSPLANTATION AND SURGERY
影响因子：
--
作者：
Bradham, CA;Schemmer, P;Brenner, DA
通讯作者：
Brenner, DA
DOI：
10.1073/pnas.94.4.1441
发表时间：
1997-02-18
影响因子：
11.1
作者：
Yamada, Y;Kirillova, I;Fausto, N
通讯作者：
Fausto, N
影响因子：
15.9
作者：
Campbell, JS;Prichard, L;Fausto, N
通讯作者：
Fausto, N