A Pan-Cancer Analysis of the Oncogenic Role of Twinfilin Actin Binding Protein 1 in Human Tumors.
A Pan-Cancer Analysis of the Oncogenic Role of Twinfilin Actin Binding Protein 1 in Human Tumors.
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DOI：
10.3389/fonc.2021.692136
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发表时间：
2021
影响因子：
4.7
通讯作者：
Chen P
中科院分区：
文献类型：
--
作者：
Huo G;Wang Y;Chen J;Song Y;Zhang C;Guo H;Zuo R;Zhu F;Cui J;Chen W;Chen W;Chen P
了解人类肿瘤中驱动致癌过程的共同和独特机制对于开发有效的治疗方法是必不可少的。近年来的研究表明，Twinfilin Actin Binding Protein 1（TWF1）可能是肺癌、胰腺癌和乳腺癌的驱动基因，但还没有系统的泛癌分析。在这里，我们使用TCGA（癌症基因组图谱），GEO（基因表达综合数据集）数据集，人类蛋白质图谱（HPA）和几种生物信息学工具来探索TWF1在33种肿瘤类型中的作用。作为我们分析的一部分，我们评估了肿瘤中TWF1的表达。我们发现，对于具有高TWF 1表达的肿瘤患者，如间皮瘤、肺腺癌、宫颈癌和胰腺癌，TWF 1的过表达通常预测较差的OS。我们还评估了肿瘤中TWF1的突变负荷和肿瘤患者的TWF1相关生存率，比较了正常和原发性肿瘤组织中TWF1的磷酸化，并探讨了TWF1介导的肿瘤发生中的假定功能机制。我们的泛癌症分析提供了TWF1在多种人类癌症中的致癌作用的全面概述。
Understanding common and unique mechanisms driving oncogenic processes in human tumors is indispensable to develop efficient therapies. Recent studies have proposed Twinfilin Actin Binding Protein 1 (TWF1) as a putative driver gene in lung cancer, pancreatic cancer and breast cancer, however a systematic pan-cancer analysis has not been carried out. Here, we set out to explore the role of TWF1 in 33 tumor types using TCGA (The Cancer Genome Atlas), GEO (Gene Expression Omnibus) dataset, Human Protein Atlas (HPA), and several bioinformatic tools. As part of our analysis, we have assessed TWF1 expression across tumors. We found that over-expression of TWF1 generally predicted poor OS for patients with tumors with high TWF1 expression, such as mesothelioma, lung adenocarcinoma, cervical cancer and pancreatic adenocarcinoma. We also assessed the mutation burden of TWF1 in cancer and the TWF1-associated survival of cancer patients, compared the phosphorylation of TWF1 between normal and primary tumor tissues and explored putative functional mechanisms in TWF1-mediated oncogenesis. Our pan-cancer analysis provides a comprehensive overview of the oncogenic roles of TWF1 in multiple human cancers.
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通讯作者：
Goode, BL
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Liu H
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影响因子：
--
作者：
Liu C;Zhang S;Wang Q;Zhang X
通讯作者：
Zhang X