Cytochrome P450 regulation: the interplay between its heme and apoprotein moieties in synthesis, assembly, repair, and disposal.
Cytochrome P450 regulation: the interplay between its heme and apoprotein moieties in synthesis, assembly, repair, and disposal.
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DOI：
10.3109/03602532.2010.515222
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发表时间：
2011-02
影响因子：
5.9
通讯作者：
De Matteis F
中科院分区：
文献类型：
--
作者：
Correia MA;Sinclair PR;De Matteis F
血红素对我们的有氧世界至关重要。血红素细胞含量是通过精细的合成和降解控制微调。血红素缺乏对细胞有害，而过量的血红素是有毒的。大多数细胞血红素充当功能多样的血红蛋白的假体片段，包括细胞色素P450 （P450）。在肝脏中，p450是其主要消耗者，约有50%的肝血红素致力于p450的合成。假体血红素是P450催化生物转化的必要条件内和外源。除了这种公认的功能作用外，血红素还调节P450蛋白的合成、组装、修复和处置。这些不太受重视的方面在这里进行了回顾。
Heme is vital to our aerobic universe. Heme cellular content is finely tuned through an exquisite control of synthesis and degradation. Heme deficiency is deleterious to cells, whereas excess heme is toxic. Most of the cellular heme serves as the prosthetic moiety of functionally diverse hemoproteins, including cytochromes P450 (P450s). In the liver, P450s are its major consumers with >50% of hepatic heme committed to their synthesis. Prosthetic heme is the sine qua non of P450 catalytic biotransformation of both endo- and xenobiotics. This well-recognized functional role notwithstanding, heme also regulates P450 protein synthesis, assembly, repair and disposal. These less well-appreciated aspects are reviewed herein.
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影响因子：
4.8
作者：
Berlanga, JJ;Herrero, S;de Haro, C
通讯作者：
de Haro, C
影响因子：
6.1
作者：
BRADY, AM;LOCK, EA
通讯作者：
LOCK, EA
影响因子：
4.1
作者：
BONKOVSKY, HL;SINCLAIR, JF;SMITH, EL
通讯作者：
SMITH, EL
影响因子：
3.9
作者：
BHAT, GJ;PADMANABAN, G
通讯作者：
PADMANABAN, G
DOI：
10.1046/j.1432-1327.1998.2580820.x
发表时间：
1998-12-01
期刊：
EUROPEAN JOURNAL OF BIOCHEMISTRY
影响因子：
--
作者：
Chefalo, PJ;Oh, JH;Chen, JJ
通讯作者：
Chen, JJ