Mildly elevated TSH and cognition in middle-aged and older adults.
Mildly elevated TSH and cognition in middle-aged and older adults.
复制标题
中老年人 TSH 和认知轻度升高。
DOI：
10.1089/thy.2008.0226
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
Mack,WendyJ
中科院分区：
文献类型：
--
作者：
StJohn,JanA;Henderson,VictorW;Gatto,NicoleM;McCleary,CarolA;Spencer,CaroleA;Hodis,HowardN;Mack,WendyJ
Background:It is accepted that markedly elevated thyroid-stimulating hormone (TSH) levels are associated with impaired cognitive function. However, the findings regarding the association between mildly elevated TSH levels and cognition are equivocal. The objective of this study was to assess the relation between TSH levels in the normal to mildly elevated range (0.3–10.0 mIU/L) and several domains of cognitive function.Methods:A healthy, community-based sample of 489 men and women (40–88 years old, mean = 60.5 years) enrolled in the B-Vitamin Atherosclerosis Intervention Trial were studied. A neuropsychological test battery was used to assess a broad array of cognitive functions. Four uncorrelated neuropsychological factors were extracted by principal component analysis. Using multivariable linear regression, performance on each factor was examined in relation to TSH levels, controlling for age, gender, race-ethnicity, education, homocysteine levels, low-density lipoprotein cholesterol levels, and smoking status.Results:TSH levels were not associated with any of the four factor scores in the total sample or in younger (age < 60) or older (age ≥ 60) subjects, although there was a trend for older subjects with higher levels of TSH to do more poorly on paragraph recall (p= 0.06). Gender-stratified analyses showed that TSH was positively associated with scores on word list learning for females only (p= 0.003).Conclusions:In this community-based sample of middle-aged to older individuals, increasing TSH levels were not associated with significantly reduced cognitive performance in any domain. Further exploration of the effects of gender on the association between TSH and cognition is warranted.
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DOI：
--
发表时间：
2007-03
期刊：
Minerva endocrinologica
影响因子：
--
作者：
Jennifer D. Davis;G. Tremont
通讯作者：
Jennifer D. Davis;G. Tremont
影响因子：
39.2
作者：
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亚临床甲状腺功能减退症：神经行为特征和 L-甲状腺素治疗的有益效果
DOI：
--
发表时间：
1993
期刊：
Clinical Investigation
影响因子：
--
作者：
F. Monzani;P. Guerra;N. Caraccio;C. Pruneti;E. Pucci;M. Luisi;L. Baschieri
通讯作者：
L. Baschieri
影响因子：
5
作者：
Morris, MS;Jacques, PF;Rosenberg, IH
通讯作者：
Rosenberg, IH
影响因子：
5.8
作者：
Samuels, M. H.;Schuff, K. G.;Janowsky, J. S.
通讯作者：
Janowsky, J. S.