The pathomechanisms of psoriasis; the skin immune system and cyclosporin
The pathomechanisms of psoriasis; the skin immune system and cyclosporin
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牛皮癣的发病机制；
DOI：
10.1111/j.1365-2133.1988.tb01768.x
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发表时间：
1988
影响因子：
10.3
通讯作者：
J. Bos
中科院分区：
文献类型：
--
作者：
J. Bos
银屑病是一种常见的慢性疾病，具有复杂的遗传性，病因尚不清楚。必须存在一个或多个原发性anu基因决定的缺陷，但尚未确定。皮肤症状几乎总是存在，而少数患者有五种形式的关节炎之一。“自从Krueger发表了关于银屑病发病机制的优秀综述以来，大量的出版物扩展了我们对所涉及的二级和三级病理机制的认识。本综述提出了三个标题下的研究方法：细胞，细胞间和细胞内。表i列出了可能涉及的因素。就细胞内病理机制而言，重点放在质膜信号转导系统。银屑病中涉及的细胞亚型与皮肤免疫系统的成分之间的相似性被指出。最近推出的抗银屑病药物环孢菌素，通常作为一种免疫抑制剂使用的药物，六种可能的作用模式，然后描述。必须强调的是，银屑病目前尚未被明确证实是一种原发性免疫性疾病。然而，支持免疫假说的间接证据正在增加，这可以从这里描述的银屑病研究的一些最新进展中看出。
Psoriasis is a common and chronic disease with a complex heredity and an as yet unknown aetiology. One or more primary anu genetically determined defects must be present, but have not been identified as yet. Skin symptoms are almost always present while a minority of patients have one of five forms of arthritis.' Since the publication of the excellent review on the pathogenesis of psoriasis by Krueger,a large number of publications has extended our knowledge of the secondary and tertiary pathomechanisms involved. The present review presents the investigational approaches under three headings: cellular, intercellular and intracellular. The possible factors involved are listed in Table i. As far as intracellular pathomechanisms are concerned, emphasis is placed on the plasma membrane signal transducing systems. The similarity between the cellular subtypes involved in psoriasis and the constituents of the skin immune system^ is indicated. The six possible modes of action of the recently introduced antipsoriatic drug cyclosporin, a drug generally in use as an immunosuppressant, are then described. It must be stressed that, at presem, psoriasis has still not been proved definitively to be a primary immunological disease. Circumstantial evidence supporting the immunological hypothesis is increasing however, as can be seen from some of the recent developments in psoriasis research described here.
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单克隆抗体与 A 组链球菌以及正常和银屑病人类皮肤发生交叉反应。
DOI：
10.1111/1523-1747.ep12524838
发表时间：
1986
期刊：
The Journal of investigative dermatology
影响因子：
--
作者：
Swerlick,RA;Cunningham,MW;Hall,NK
通讯作者：
Hall,NK
环孢素与钙调蛋白的结合是否会导致免疫抑制？
DOI：
10.1126/science.3749892
发表时间：
1986
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
LeGrue,SJ;Turner,R;Weisbrodt,N;Dedman,JR
通讯作者：
Dedman,JR
影响因子：
6.5
作者：
NANNEY, LB;STOSCHECK, CM;KING, LE
通讯作者：
KING, LE
通过正常和牛皮癣皮肤的酶制剂生物合成脂氧合酶产品。
DOI：
10.1111/1523-1747.ep12273519
发表时间：
1984
期刊：
The Journal of investigative dermatology
影响因子：
--
作者：
Ziboh,VA;Casebolt,TL;Marcelo,CL;Voorhees,JJ
通讯作者：
Voorhees,JJ