Revisiting the Role of Natural Killer Cells in Non-Alcoholic Fatty Liver Disease.
Revisiting the Role of Natural Killer Cells in Non-Alcoholic Fatty Liver Disease.
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DOI：
10.3389/fimmu.2021.640869
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发表时间：
2021
影响因子：
7.3
通讯作者：
Beraza N
中科院分区：
文献类型：
--
作者：
Martínez-Chantar ML;Delgado TC;Beraza N
非酒精性脂肪肝病（NAFLD）是最常见的慢性肝病。 NAFLD 的组织学范围从简单的脂肪变性到非酒精性脂肪性肝炎 (NASH) 期间的慢性炎症和肝纤维化。目前的观点是，先天免疫机制是支持 NASH 肝脏炎症的关键因素。自然杀伤 (NK) 细胞是淋巴细胞，是已知参与 NASH 进展的先天免疫系统的组成部分。越来越多的证据揭示了循环和组织驻留 NK 细胞的差异功能，以及代谢和微环境在调节其活性方面的相关性。在这里，我们重新审视 NK 细胞作为 NASH 进展调节因子的复杂作用，以及基于其调节的潜在治疗方法。
Non-Alcoholic Fatty Liver Disease (NAFLD) is the most common form of chronic liver disease. The histological spectrum of NAFLD ranges from simple steatosis to chronic inflammation and liver fibrosis during Non-Alcoholic Steatohepatitis (NASH). The current view is that innate immune mechanisms represent a key element in supporting hepatic inflammation in NASH. Natural Killer (NK) cells are lymphoid cells and a component of the innate immune system known to be involved in NASH progression. Increasing evidence has shed light on the differential function of circulating and tissue-resident NK cells, as well as on the relevance of metabolism and the microenvironment in regulating their activity. Here, we revisit the complex role of NK cells as regulators of NASH progression as well as potential therapeutic approaches based on their modulation.
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影响因子：
29.4
作者：
Cotter, Thomas G.;Rinella, Mary
通讯作者：
Rinella, Mary
DOI：
10.1084/jem.20082152
发表时间：
2009-08-03
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Beraza N;Malato Y;Sander LE;Al-Masaoudi M;Freimuth J;Riethmacher D;Gores GJ;Roskams T;Liedtke C;Trautwein C
通讯作者：
Trautwein C
影响因子：
29.4
作者：
Gehrke, Nadine;Schattenberg, Joern M.
通讯作者：
Schattenberg, Joern M.
影响因子：
13.5
作者：
Fujita, Koji;Nozaki, Yuichi;Nakajima, Atsushi
通讯作者：
Nakajima, Atsushi
影响因子：
5.1
作者：
Amer J;Salhab A;Noureddin M;Doron S;Abu-Tair L;Ghantous R;Mahamid M;Safadi R
通讯作者：
Safadi R