The role of chemokines in leucocyte-stromal interactions in rheumatoid arthritis.
The role of chemokines in leucocyte-stromal interactions in rheumatoid arthritis.
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趋化因子在类风湿关节炎中白细胞 - 基质相互作用中的作用。
DOI：
10.2741/2874
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发表时间：
2008-01-01
期刊：
影响因子：
--
通讯作者：
Buckley CD
中科院分区：
文献类型：
--
作者：
Filer A;Raza K;Salmon M;Buckley CD
趋化因子及其受体的发现为我们理解免疫细胞在健康和疾病中的运输开辟了新的维度。该化学引诱细胞因子家族在组织微环境中白细胞亚群的募集和随后的定位中起重要作用。趋化因子网络的研究提供了一种新的方法来了解炎症细胞在类风湿性关节炎（RA）等疾病中持续存在的机制，其中越来越多的证据表明，趋化因子和/或其受体的不适当的时空表达可能会损害白细胞浸润的分辨率。基质细胞如成纤维细胞作为组织特异性微环境的活性成分，能够决定炎性浸润的类型和持续性，这一认识为研究开辟了新的前景。基质细胞是细胞因子和炎性趋化因子网络的积极贡献者，其导致免疫细胞募集和活化。然而，基质细胞在组成型管家趋化因子的不适当表达中的有趣作用已被证明，其通过积极阻断炎症的消退而导致炎症的持续存在。
New dimensions in our understanding of immune cell trafficking in health and disease have been opened by the discovery of chemokines and their receptors. This family of chemo-attractant cytokines performs essential roles in the recruitment and subsequent positioning of leucocyte subsets within tissue microenvironments. Investigation of chemokine networks offers a novel approach to understand the mechanisms by which inflammatory cells persist in diseases such as rheumatoid arthritis (RA), where evidence is mounting that the inappropriate temporal and spatial expression of chemokines and/or their receptors may impair the resolution of leucocyte infiltrates. The recognition that stromal cells such as fibroblasts, as active components of tissue specific microenvironments, are able to determine the type and persistence of inflammatory infiltrates has opened new vistas in research. Stromal cells are active contributors to cytokine and inflammatory chemokine networks which result in immune cell recruitment and activation. However an intriguing role of stromal cells has been demonstrated in the inappropriate expression of constitutive, housekeeping chemokines, which contribute to the persistence of inflammation by actively blocking its resolution.
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DOI：
10.1186/ar5
发表时间：
1999
期刊：
Arthritis research
影响因子：
--
作者：
Dayer JM;Burger D
通讯作者：
Burger D
影响因子：
15.3
作者：
Gong, JH;Ratkay, LG;Waterfield, JD;ClarkLewis, I
通讯作者：
ClarkLewis, I
影响因子：
5.4
作者：
DApuzzo, M;Rolink, A;Moser, B
通讯作者：
Moser, B
影响因子：
--
作者：
Haringman, Jasper J.;Gerlag, Danielle M.;Tak, Paul P.
通讯作者：
Tak, Paul P.
影响因子：
16.8
作者：
Buckley, CD;Pilling, D;Salmon, M
通讯作者：
Salmon, M