Pneumococcal whole-cell and protein-based vaccines: changing the paradigm.
Pneumococcal whole-cell and protein-based vaccines: changing the paradigm.
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DOI：
10.1080/14760584.2017.1393335
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发表时间：
2017-12
影响因子：
6.2
通讯作者：
Pichichero ME
中科院分区：
文献类型：
--
作者：
Pichichero ME
Epidemiologic evaluations of Streptococcus pneumoniae nasopharyngeal (NP) colonization and pneumococcal disease suggest that newer serotypes in future formulations of pneumococcal conjugate vaccines (PCVs) are needed and there may need to be continued reformulations because there are many new emerging serotypes expressed by pneumococci. Mechanisms of protection by next-generation whole-cell vaccine (WCV) and/or multi-component pneumococcal purified protein vaccines (PPVs) in development for prevention of pneumococcal infections. A long-term strategy for prevention of pneumococcal disease will likely include WCV and PPVs. However these vaccines will impact disease pathogenesis in a different manner than PCVs. Prevention of pneumococcal NP colonization should not be expected, nor is it desirable because risks for NP colonization by other replacement organisms into the ecological niche vacated by all pneumococci may have consequences. The expression biology of capsule and surface protein antigens are phase dependent. Therefore, the immune response will be different and the mechanism of protection divergent. WCVs and PPVs may be alternative strategies in low income developing countries to protect against invasive disease and reduce NP carriage load.
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影响因子：
6.4
作者：
BUTLER, JC;BREIMAN, RF;FACKLAM, RR
通讯作者：
FACKLAM, RR
影响因子：
5.5
作者：
Devine, Vanessa T.;Cleary, David W.;Clarke, Stuart C.
通讯作者：
Clarke, Stuart C.
影响因子：
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作者：
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通讯作者：
Goncalves, Viviane M.
影响因子：
5.5
作者：
Dagan, Ron;Juergens, Christine;Scott, Daniel A.
通讯作者：
Scott, Daniel A.
DOI：
10.1016/j.jaci.2016.12.985
发表时间：
2017-11
期刊：
The Journal of allergy and clinical immunology
影响因子：
--
作者：
Dowling DJ;Scott EA;Scheid A;Bergelson I;Joshi S;Pietrasanta C;Brightman S;Sanchez-Schmitz G;Van Haren SD;Ninković J;Kats D;Guiducci C;de Titta A;Bonner DK;Hirosue S;Swartz MA;Hubbell JA;Levy O
通讯作者：
Levy O