Role of microenvironmental acidity and tumor exosomes in cancer immunomodulation.
Role of microenvironmental acidity and tumor exosomes in cancer immunomodulation.
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微环境酸度和肿瘤外泌体在癌症免疫调节中的作用。
DOI：
10.21037/tcr.2020.03.69
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发表时间：
2020-09
影响因子：
0.9
通讯作者：
Parolini I
中科院分区：
文献类型：
--
作者：
Boussadia Z;Zanetti C;Parolini I
肿瘤微环境（TME）是一个复杂的环境，在其中肿瘤通过与免疫细胞、基质细胞和细胞外基质（ECM）的复杂双向交互作用而生长、发展和进展。在这种情况下，肿瘤来源的外泌体（TE）通过对免疫系统的刺激或抑制作用驱动肿瘤细胞的命运。事实上，TE可以诱导免疫监视细胞的凋亡，并增强维持肿瘤发展的基质细胞的增殖和存活。然而，根据分子货物，TE也能够刺激抗肿瘤免疫应答。TME的主要特征在于酸性pH，其通过多种机制促进肿瘤发展。其中，肿瘤免疫监视的损害确实发生在酸性TME内，并且由酸性pH或TE携带的分子货物直接介导。关于TE在酸性条件下的免疫调节作用知之甚少。本文综述了微环境酸度和TE在免疫系统调节中的作用。
Tumor microenvironment (TME) is a complex milieu in which tumor grows, develops and progresses through a complex bi-directional cross-talk with immune-, stromal cells, and the extracellular matrix (ECM). In this context, tumor-derived exosomes (TE) drive the fate of tumor cells through a stimulatory or inhibitory role on immune system. In fact, TE can induce the apoptosis of cells of the immune surveillance, and enhance the proliferation and survival of stromal cells that sustain tumor development. However, depending on the molecular cargo, TE are also able to stimulate anti-tumor immune response. TME is mainly characterized by the acidic pH that contributes to tumor development, through multiple mechanisms. Among these, the impairment of tumor immune surveillance does occur within acidic TME, and is directly mediated by acidic pH or by molecular cargo carried by TE. Little is known about the role of TE in immunomodulation in acidic conditions. The present review summarizes the studies describing the role of microenvironmental acidity and TE in immune system modulation.
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影响因子：
--
作者：
Ding G;Zhou L;Qian Y;Fu M;Chen J;Chen J;Xiang J;Wu Z;Jiang G;Cao L
通讯作者：
Cao L
影响因子：
11.2
作者：
Ashiru O;Boutet P;Fernández-Messina L;Agüera-González S;Skepper JN;Valés-Gómez M;Reyburn HT
通讯作者：
Reyburn HT
影响因子：
64.8
作者：
De Henau O;Rausch M;Winkler D;Campesato LF;Liu C;Cymerman DH;Budhu S;Ghosh A;Pink M;Tchaicha J;Douglas M;Tibbitts T;Sharma S;Proctor J;Kosmider N;White K;Stern H;Soglia J;Adams J;Palombella VJ;McGovern K;Kutok JL;Wolchok JD;Merghoub T
通讯作者：
Merghoub T
影响因子：
7.3
作者：
Barros FM;Carneiro F;Machado JC;Melo SA
通讯作者：
Melo SA
激活的 T 细胞外泌体通过 Fas 信号通路促进肿瘤侵袭
影响因子：
4.4
作者：
Cai, Zhijian;Yang, Fei;Wang, Jianli
通讯作者：
Wang, Jianli