Immunobiology of genital tract trauma: endocrine regulation of HIV acquisition in women following sexual assault or genital tract mutilation.
Immunobiology of genital tract trauma: endocrine regulation of HIV acquisition in women following sexual assault or genital tract mutilation.
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DOI：
10.1111/aji.12027
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发表时间：
2013-02
期刊：
影响因子：
--
通讯作者：
Wira CR
中科院分区：
文献类型：
--
作者：
Ghosh M;Rodriguez-Garcia M;Wira CR
对一生中遭受过性创伤的妇女艾滋病毒感染和传播的研究尚缺乏，但一些研究结果表明，通过强迫性行为感染艾滋病毒的比率明显高于双方同意的性行为。切割女性生殖器官也可能造成性创伤，这使性行为极其痛苦，并可能导致更多的擦伤、撕裂和炎症，从而增加感染艾滋病毒的风险。这篇综述介绍了免疫系统在人类女性生殖道从青春期，通过青春期，怀孕和更年期的概述。显而易见的是，在妇女整个生命周期中，关于女性生殖道免疫保护的信息基础极为有限，在青春期和更年期等某些阶段更是严重缺乏。在这种背景下，强迫或强制性交以及生殖器切割使我们对可能导致艾滋病毒和其他性传播感染传播的生物学风险因素的理解进一步复杂化。
Studies on HIV acquisition and transmission in women exposed to sexual trauma throughout their life cycle are lacking but some findings suggest that rates of HIV acquisition through coercive sex are significantly higher than that seen in consensual sex. Sexual trauma can also occur as a result of female genital mutilation, which makes sex extremely painful and can cause increased abrasions, lacerations and inflammation, which enhances the risk of HIV acquisition. This review presents an overview of the immune system in the human female reproductive tract from adolescence, through puberty to pregnancy and menopause. What is clear is that the foundation of information on immune protection in the female reproductive tract throughout the life cycle of women is extremely limited and at some stages such as adolescence and menopause are grossly lacking. Against this back backdrop, forced or coercive sexual intercourse as well as genital mutilation further complicates our understanding of the biological risk factors that can result in transmission of HIV and other sexually transmitted infections.
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DOI：
10.1186/1477-7827-9-118
发表时间：
2011-08-23
期刊：
Reproductive biology and endocrinology : RB&E
影响因子：
--
作者：
Escribese MM;Rodríguez-García M;Sperling R;Engel SM;Gallart T;Moran TM
通讯作者：
Moran TM
DOI：
10.1038/nri2935
发表时间：
2011-03
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
通讯作者：
--
影响因子：
2.9
作者：
Bakhru, Arvind;Mallinger, Julie B.;Fox, Michelle C.
通讯作者：
Fox, Michelle C.
影响因子：
3.6
作者：
Casslén, B;Sandberg, T;Nilbert, M
通讯作者：
Nilbert, M
影响因子：
5.4
作者：
Ballweber, Lamar;Robinson, Barry;Hladik, Florian
通讯作者：
Hladik, Florian