Role of haptoglobin in polycystic ovary syndrome (PCOS), obesity and disorders of glucose tolerance in premenopausal women.
Role of haptoglobin in polycystic ovary syndrome (PCOS), obesity and disorders of glucose tolerance in premenopausal women.
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DOI：
10.1371/journal.pone.0005606
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发表时间：
2009
期刊：
影响因子：
3.7
通讯作者：
Escobar-Morreale HF
中科院分区：
文献类型：
--
作者：
Alvarez-Blasco F;Martínez-García MA;Luque-Ramírez M;Parraza N;San Millán JL;Escobar-Morreale HF
接触珠蛋白α -链多态性的Hp2等位基因以基因剂量的方式降低了这种急性期蛋白的抗氧化特性并增加了促炎作用。我们假设，接触珠蛋白多态性可能导致氧化应激和低级别慢性炎症的增加，这些炎症通常与多囊卵巢综合征、肥胖和糖耐量异常有关。对141例多囊卵巢综合征患者和102例非高雄激素性女性的血清haptoglobin及α -链多态性进行了检测。在243名绝经前妇女中，117名肥胖，51名糖耐量异常。尽管PCOS患者和对照组的血清触珠蛋白浓度相似，但前者Hp2等位基因的频率增加（62%对52%，P = 0.023）。循环中触珠蛋白水平随肥胖而升高（P<0.001），但肥胖与触珠蛋白基因型之间未发现关联。根据葡萄糖耐量，没有观察到珠蛋白水平或基因型频率的差异。血清中触珠蛋白浓度的50%的变化可以用血清c反应蛋白浓度、BMI、胰岛素敏感性和触珠蛋白基因型的变化来解释。绝经前妇女的血清触珠蛋白浓度在很大程度上取决于触珠蛋白多态性和肥胖的存在，胰岛素抵抗和慢性炎症可能调节这种关系。多囊卵巢综合征与Hp2等位基因的关联表明，在这些患者中，接触珠蛋白的抗氧化和抗炎特性可能会降低。
Hp2 alleles of the haptoglobin α–chain polymorphism reduce the anti-oxidant properties and increase the pro-inflammatory actions of this acute-phase protein in a gene-dosage fashion. We hypothesized that the haptoglobin polymorphism might contribute to the increased oxidative stress and low-grade chronic inflammation frequently associated with polycystic ovary syndrome, obesity, and abnormalities of glucose tolerance. Serum haptoglobin and the haptoglobin α–chain polymorphism were determined in 141 patients with polycystic ovary syndrome and 102 non-hyperandrogenic women. Of the whole group of 243 premenopausal women, 117 were obese and 51 showed abnormal glucose tolerance. Although serum haptoglobin concentrations were similar in PCOS patients and controls, the former presented with an increased frequency of Hp2 alleles (62% vs. 52%, P = 0.023). Circulating haptoglobin levels increased with obesity (P<0.001), yet no association was found between obesity and haptoglobin genotypes. No differences were observed in haptoglobin levels or genotype frequencies depending on glucose tolerance. Fifty percent of the variation in serum haptoglobin concentrations was explained by the variability in serum C-reactive protein concentrations, BMI, insulin sensitivity and haptoglobin genotypes. Serum haptoglobin concentrations in premenopausal women are largely dependent on the haptoglobin polymorphism and on the presence of obesity, with insulin resistance and chronic inflammation possibly modulating this relationship. The association of polycystic ovary syndrome with Hp2 alleles suggests that the anti-oxidant and anti-inflammatory properties of haptoglobin may be reduced in these patients.
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影响因子：
16.2
作者：
通讯作者：
--
DOI：
10.1161/01.atv.0000251020.24399.a2
发表时间：
2007-01-01
影响因子：
8.7
作者：
Levy, Andrew P.;Levy, Joanne E.;Moreno, Pedro R.
通讯作者：
Moreno, Pedro R.
影响因子：
--
作者：
Alvarez-Blasco, Francisco;Botella-Carretero, Jose I.;Escobar-Morreale, Hector F.
通讯作者：
Escobar-Morreale, Hector F.
影响因子：
3.2
作者：
Conn, JJ;Jacobs, HS;Conway, GS
通讯作者：
Conway, GS
影响因子：
16.2
作者：
Escobar-Morreale, HF;Luque-Ramírez, M;San Millán, JL
通讯作者：
San Millán, JL