Associations of Transcription Factor 21 Gene Polymorphisms with the Growth and Body Composition Traits in Broilers.
Associations of Transcription Factor 21 Gene Polymorphisms with the Growth and Body Composition Traits in Broilers.
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DOI：
10.3390/ani12030393
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发表时间：
2022-02-08
期刊：
影响因子：
--
通讯作者：
Zhang H
中科院分区：
文献类型：
--
作者：
Shen L;Yu J;Ge Y;Li H;Li Y;Cao Z;Luan P;Xiao F;Gao H;Zhang H
在这项工作中发现的功能SNPs将提供有用的信息，关键的分子标记，可用于育种工作，以改善肉鸡心脏发育。本研究旨在筛选出可用于肉鸡育种的分子标记位点。本研究利用公共数据库定位了影响肉鸡重要经济性状的转录因子21（TCF 21）基因。单克隆测序法检测TCF 21基因10个单核苷酸多态性。TCF 21基因的这10个SNPs多态性与多个生长和体组成性状显著相关（p < 0.05）。此外，g.-通过多种方法鉴定了911 T>G显著增加心脏重量性状，而不影响负面性状，如腹部脂肪和繁殖。因此，有人推测，g.-在TCF 21基因中发现的911 T>G可能用于肉鸡育种中的分子标记辅助选择。
The functional SNPs discovered in this work will give helpful information on the crucial molecular markers that may be employed in breeding efforts to improve the heart development of broiler chickens. This study aims to identify molecular marker loci that could be applied in broiler breeding programs. In this study, we used public databases to locate the Transcription factor 21 (TCF21) gene that affected the economically important traits in broilers. Ten single nucleotide polymorphisms were detected in the TCF21 gene by monoclonal sequencing. The polymorphisms of these 10 SNPs in the TCF21 gene were significantly associated (p < 0.05) with multiple growth and body composition traits. Furthermore, the TT genotype of g.-911T>G was identified to significantly increase the heart weight trait without affecting the negative traits, such as abdominal fat and reproduction by multiple methods. Thus, it was speculated that the g.-911T>G identified in the TCF21 gene might be used in marker-assisted selection in the broiler breeding program.
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影响因子：
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影响因子：
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