Model of P- and T-electroreceptors of weakly electric fish.
Model of P- and T-electroreceptors of weakly electric fish.
复制标题
弱电鱼的 P 和 T 电感受器模型。
DOI：
10.1016/s0006-3495(96)79823-5
复制
发表时间：
1996
影响因子：
3.4
通讯作者：
T. Kambara
中科院分区：
文献类型：
--
作者：
Y. Kashimori;M. Goto;T. Kambara
为了阐明P受体和T受体编码干扰信号的幅度调制和过零时间的微观机制，我们根据P受体和T受体的生理和解剖特性提出了一个模型。该模型由受体细胞、支持细胞和传入神经纤维组成。受体细胞的基底膜包括电压敏感的钙通道、钙激活的K+通道和Na+、K+、Cl-的泄漏通道。电压敏感的钙通道是刺激下电位变化的驱动力，钙激活的钾通道是电压敏感性钾通道的抑制力。研究表明，在T受体细胞中，驱动力远强于抑制力，而在P受体细胞中，驱动力与抑制力相当。P受体和T受体之间的各种反应特性的差异一直被解释为基于P受体和T受体细胞之间驱动力和抑制力的相对强度的差异。考虑的反应特性包括编码函数、传入神经放电概率、衰减振荡模式、调谐曲线形状、最佳频率值和反应潜伏期。
To clarify the microscopic mechanisms by which P- and T-receptors encode amplitude modulation and zero crossing time of jamming signals, we present a model of P- and T-receptors based on their physiological and anatomical properties. The model consists of a receptor cell, supporting cells, and an afferent nerve fiber. The basal membrane of the receptor cell includes voltage-sensitive Ca2+ channels, Ca(2+)-activated K+ channels, and leak channels of Na+, K+, and Cl-. The driving force of potential change under stimulation is generated by the voltage-sensitive Ca2+ channels, and the suppressing force of the change is generated by Ca(2+)-activated K+ channels. It has been shown that in T-receptor cells the driving force is much stronger than the suppressing force, whereas in P-receptor cells the driving force is comparable with the suppressing force. The difference in various kinds of response properties between P- and T-receptors have been consistently explained based on the difference in the relative strengths of the driving and suppressing forces between P- and T-receptor cells. The response properties considered are encoding function, probability of firing of afferent nerve, pattern of damped oscillation, shape of tuning curves, values of the optimum frequency, and response latency.
影响因子：
5.5
作者：
HODGKIN, AL;HUXLEY, AF
通讯作者：
HUXLEY, AF