Antidepressant medicine use and risk of developing diabetes during the diabetes prevention program and diabetes prevention program outcomes study.

Antidepressant medicine use and risk of developing diabetes during the diabetes prevention program and diabetes prevention program outcomes study.
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DOI:
10.2337/dc10-1033
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发表时间:
2010-12
期刊:
影响因子:
16.2
通讯作者:
Diabetes Prevention Program Research Group
Diabetes Prevention Program Research Group
中科院分区:
医学1区
文献类型:
--
作者:
Rubin RR;Ma Y;Peyrot M;Marrero DG;Price DW;Barrett-Connor E;Knowler WC;Diabetes Prevention Program Research Group

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旨在评估糖尿病预防计划 (DPP) 和糖尿病预防计划结果研究 (DPPOS) 期间抗抑郁药物的使用与患糖尿病风险之间的关联。 DPP/DPPOS 参与者每 6 个月接受一次糖尿病评估,DPP 中每 3 个月评估一次抗抑郁药物使用情况,DPPOS 中每 6 个月评估一次抗抑郁药物使用情况,中位随访时间为 10.0 年。控制与糖尿病风险相关的因素后,与不使用抗抑郁药相比,安慰剂组(调整后的风险比为 2.34 [95% CI 1.32–4.15])和生活方式组(2.48 [1.45–4.22])中,持续使用抗抑郁药与糖尿病风险相关,但二甲双胍组中的糖尿病风险与糖尿病风险无关(0.55 [0.25–1.19])。在安慰剂组和生活方式组中,持续使用抗抑郁药与糖尿病风险显着相关。测量的混杂因素和中介因素并未解释这种关联,这可能代表药物效应或反映本研究中未评估的抗抑郁药物使用者和非使用者之间的差异。
To assess the association between antidepressant medicine use and risk of developing diabetes during the Diabetes Prevention Program (DPP) and Diabetes Prevention Program Outcomes Study (DPPOS). DPP/DPPOS participants were assessed for diabetes every 6 months and for antidepressant use every 3 months in DPP and every 6 months in DPPOS for a median 10.0-year follow-up. Controlled for factors associated with diabetes risk, continuous antidepressant use compared with no use was associated with diabetes risk in the placebo (adjusted hazard ratio 2.34 [95% CI 1.32–4.15]) and lifestyle (2.48 [1.45–4.22]) arms, but not in the metformin arm (0.55 [0.25–1.19]). Continuous antidepressant use was significantly associated with diabetes risk in the placebo and lifestyle arms. Measured confounders and mediators did not account for this association, which could represent a drug effect or reflect differences not assessed in this study between antidepressant users and nonusers.
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