Effects of Moderate Alcohol Consumption in Non-Alcoholic Fatty Liver Disease.
Effects of Moderate Alcohol Consumption in Non-Alcoholic Fatty Liver Disease.
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DOI：
10.3390/jcm11030890
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发表时间：
2022-02-08
影响因子：
3.9
通讯作者：
Sydor S
中科院分区：
文献类型：
--
作者：
Lemmer P;Manka P;Best J;Kahraman A;Kälsch J;Vilchez-Vargas R;Link A;Chiang H;Gerken G;Canbay A;Bechmann LP;Sydor S
酒精性肝病（ALD）和非酒精性脂肪肝病（NAFLD）已成为全球慢性肝病的主要原因。 ALD 和 NAFLD 具有多种病理生理学模式和组织学特征，但在临床上，它们通过每日饮酒量来区分。然而，在越来越多的人口中，NAFLD 与适度饮酒并存。在这里，我们研究了适量饮酒对 30 名 NAFLD 患者的肝损伤、脂质代谢和肠道微生物群的影响。我们采用 AUDIT 和 CAGE 问卷匿名评估饮酒习惯，并比较戒酒者亚组与低度至有害酒精消费者 (AUDIT) 以及 Cage 0-1 与 Cage 2-4。不饮酒的患者的 γGT、ALT、甘油三酯和总胆固醇水平较低。虽然低度至有害饮酒人群中拟杆菌科、双歧杆菌科、链球菌科和瘤胃球菌科的丰度较高，但戒酒者中理肯氏菌科的丰度较高。我们的研究表明，即使适量饮酒也会对肝脏和脂质代谢以及肠道微生物群的组成产生影响。
Alcoholic liver disease (ALD) and non-alcoholic fatty liver disease (NAFLD) have emerged as leading causes of chronic liver diseases worldwide. ALD and NAFLD share several pathophysiological patterns as well as histological features, while clinically, they are distinguished by the amount of alcohol consumed daily. However, NAFLD coexists with moderate alcohol consumption in a growing proportion of the population. Here, we investigated the effects of moderate alcohol consumption on liver injury, lipid metabolism, and gut microbiota in 30 NAFLD-patients. We anonymously assessed drinking habits, applying the AUDIT- and CAGE-questionnaires and compared subgroups of abstainers vs. low to harmful alcohol consumers (AUDIT) and Cage 0–1 vs. Cage 2–4. Patients who did not drink any alcohol had lower levels of γGT, ALT, triglycerides, and total cholesterol. While the abundance of Bacteroidaceae, Bifidobacteriaceae, Streptococcaceae, and Ruminococcaceae was higher in the low to harmful alcohol drinking cohort, the abundance of Rikenellaceae was higher in the abstainers. Our study suggests that even moderate alcohol consumption has an impact on the liver and lipid metabolism, as well as on the composition of gut microbiota.
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DOI：
10.1038/ijo.2015.84
发表时间：
2015-09
期刊：
International journal of obesity (2005)
影响因子：
--
作者：
Byrne CS;Chambers ES;Morrison DJ;Frost G
通讯作者：
Frost G
影响因子：
64.8
作者：
Fu, Suneng;Yang, Ling;Li, Ping;Hofmann, Oliver;Dicker, Lee;Hide, Winston;Lin, Xihong;Watkins, Steven M.;Ivanov, Alexander R.;Hotamisligil, Goekhan S.
通讯作者：
Hotamisligil, Goekhan S.
影响因子：
8.2
作者：
通讯作者：
--
影响因子：
8.4
作者：
通讯作者：
--
DOI：
10.1111/j.1440-1746.2007.05002.x
发表时间：
2007-06-01
影响因子：
4.1
作者：
Farrell, Geoffrey C.;Chitturi, Shivakumar;Sollano, Jose D.
通讯作者：
Sollano, Jose D.