PrEP Chicago: A randomized controlled peer change agent intervention to promote the adoption of pre-exposure prophylaxis for HIV prevention among young Black men who have sex with men.
PrEP Chicago: A randomized controlled peer change agent intervention to promote the adoption of pre-exposure prophylaxis for HIV prevention among young Black men who have sex with men.
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DOI：
10.1177/1740774517730012
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发表时间：
2018-03
期刊：
影响因子：
--
通讯作者：
Schneider JA
中科院分区：
文献类型：
--
作者：
Young LE;Schumm P;Alon L;Bouris A;Ferreira M;Hill B;Khanna AS;Valente TW;Schneider JA
暴露前预防 (PrEP) 等生物医学预防策略的进步为降低男男性行为黑人 (MSM) 的艾滋病毒发病率提供了新的机会，而对于这些人来说，新发艾滋病毒感染的数量持续上升。然而，研究表明该社区 PrEP 的采用率较低。研究表明，年轻黑人男男性接触者的同伴网络在他们的性健康决策中发挥着重要作用。芝加哥 PrEP 是一项随机对照试验网络干预措施，旨在提高居住在芝加哥的年轻黑人 MSM 的 PrEP 接受率。这项研究的目的是双重的。目标 1 是评估同伴变革推动者干预的有效性：1) 增加 PrEP 信息热线的转介数量； 2) 提高非参与者同行中 PrEP 采用率； 3) 提高参与者的 PrEP 知识、态度和意图。目标 2 是确定解释同伴变革推动者有效性的个人和网络变量。芝加哥 PrEP 是一种社交网络干预措施，利用同伴变革推动者的影响力将芝加哥年轻的黑人 MSM 与 PrEP 联系起来。年轻的黑人 MSM 参与者是通过受访者驱动的抽样来招募的。一旦筛选出资格，参与者被随机分配到两个治疗序列之一：1）第 1 年进行干预治疗，然后在第 2 年进行最小接触注意控制，或 2）第 1 年进行最小接触注意控制，然后在第 2 年进行治疗。治疗包括 PrEP/同侪改变剂培训研讨会，然后是为期 12 个月的加强呼吁。注意力控制包括性日记活动，旨在帮助参与者评估性风险。从所有参与者的基线以及 12 个月和 24 个月的随访中收集心理社会、性健康和网络数据。总共有 423 名 18-35 岁的参与者入组（超过目标入组率 100%），并已完成基线数据收集。干预组和对照组的大多数参与者都表示在参加研究之前听说过 PrEP，但也表示目前或之前没有服用 PrEP 的经验。统计分析将于 2018 年 3 月完成第一年的试验。芝加哥 PrEP 通过利用年轻黑人 MSM 中现有的社交网络作为信息传播、行为影响、社会支持和赋权的机制，填补了艾滋病毒预防研究和干预设计方面的空白。因此，利用同伴影响过程来促进 PrEP 吸收的干预措施是改善性健康参与并克服这一高危人群结果差异的有前景的策略。
Advances in biomedical prevention strategies such as Pre-Exposure Prophylaxis (PrEP) represent a new opportunity for reducing HIV incidence among young Black men who have sex with men (MSM), for whom the number of new HIV infections continues to rise. However, studies have documented low rates of PrEP uptake in this community. Research suggests that the peer networks of young Black MSM play important roles in their sexual health decisions. PrEP Chicago is a randomized controlled trial network intervention designed to increase PrEP uptake among young Black MSM living in Chicago. The aims of this study are twofold. Aim 1 is to estimate the effectiveness of a peer change agent intervention for: 1) increasing the number of referrals made to a PrEP information line; 2) increasing the rate of PrEP adoption among non-participant peers; and 3) increasing PrEP knowledge, attitudes and intentions among participants. Aim 2 is to determine the individual and network variables that explain peer change agent effectiveness. PrEP Chicago is a social network intervention that utilizes the influence of peer change agents to link young Black MSM in Chicago to PrEP. Young Black MSM participants were recruited using respondent-driven sampling. Once screened for eligibility, participants were randomly assigned to either one of two treatment sequences: 1) intervention treatment in Year 1 followed by a minimal contact attention control in Year 2, or 2) the minimal contact attention control in Year 1 followed by treatment in Year 2. The treatment consists of a PrEP/peer change agent training workshop followed by booster calls for 12 months. The attention control consists of a sex diary activity designed to help participants assess sexual risk. Psychosocial, sexual health, and network data are collected from all participants at baseline and at 12- and 24-month follow-ups. In total, 423 participants aged 18–35 have been enrolled (more than 100% target enrollment) and have completed baseline data collection. A majority of participants in both intervention and control groups reported having heard of PrEP before enrolling in the study, yet also reported having had no current or prior experience taking PrEP. Statistical analyses await completion of Year 1 of the trial in March 2018. PrEP Chicago addresses a gap in HIV prevention research and intervention design by utilizing the existing social networks among young Black MSM as mechanisms for information diffusion, behavioral influence, social support and empowerment. Therefore, interventions that leverage peer influence processes to facilitate PrEP uptake are promising strategies to improve sexual health engagement and overcome disparities in outcomes among this at-risk population.
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影响因子：
4.4
作者：
Ghosh, Debarchana;Krishnan, Archana;Gibson, Britton;Brown, Shan-Estelle;Latkin, Carl A.;Altice, Frederick L.
通讯作者：
Altice, Frederick L.
DOI：
10.1080/13691058.2014.905706
发表时间：
2014-06
期刊：
Culture, health & sexuality
影响因子：
--
作者：
Arnold EA;Rebchook GM;Kegeles SM
通讯作者：
Kegeles SM
影响因子：
4.9
作者：
Eaton, Lisa A.;Driffin, Daniel D.;Conway-Washington, Christopher
通讯作者：
Conway-Washington, Christopher
影响因子：
1
作者：
Bauermeister, Jose A.;Meanley, Steven;Harper, Gary W.
通讯作者：
Harper, Gary W.
影响因子：
12.7
作者：
KELLY, JA;LAWRENCE, JSS;ANDREW, ME
通讯作者：
ANDREW, ME