Adaptation of simple molecular networks to time‐dependent stimulus
Adaptation of simple molecular networks to time‐dependent stimulus
复制标题
简单分子网络对时间依赖性刺激的适应
DOI：
10.1002/asjc.375
复制
发表时间：
2011
影响因子：
2.4
通讯作者：
Ruiqi Wang
中科院分区：
文献类型：
--
作者：
Xiao Chang;Dengyu Liu;Zengrong Liu;Luonan Chen;Ruiqi Wang
适应是信号系统在对刺激做出反应后自我重置的能力。非相干前馈环路和负反馈环路是显示出对恒定刺激的自适应的仅有的两种类型的三节点拓扑。在这项研究中，讨论了这两种类型的拓扑对时间依赖刺激的适应。通过解析计算和数值模拟发现，当脉冲宽度和内部参数设置适当时，它们可以表现出自适应特性。特别地，对于非相干前馈回路，考虑了两种模型，即逻辑逼近分段线性方程和Hill-型方程。当考虑对依赖于时间的刺激的适应时，逻辑近似分段线性方程的解析解与Hill类型方程的数值模拟基本一致。对时间依赖刺激的适应研究可以作为一本手册，为开发智能治疗策略和构建具有特定功能的生物电路提供不同的可能解决方案。
Adaptation is the ability by which signaling systems reset themselves after responding to a stimulus. Incoherent feedforward loops and negative feedback loops are the only two types of three‐node topologies showing adaptation to constant stimuli. In this study, adaptation of these two types of topologies to time‐dependent stimuli are discussed. Through analytical calculation and numerical simulations, it is found that they may show adaptation when the pulse duration and internal are properly assigned. In particular, for incoherent feedforward loops, two kind of models, i.e., logic approximation piecewise‐linear equations and Hill‐type equations are considered. When adaptation to time‐dependent stimulus is considered, analytical solutions for logic approximation piecewise‐linear equations and numerical simulation for Hill‐type equations are in substantial agreement. The study on adaptation to time‐dependent stimulus could serve as a manual providing different possible solutions to develop intelligent therapeutic strategies and to build biological circuits with specified functions.
影响因子：
56.9
作者：
De Koninck, P;Schulman, H
通讯作者：
Schulman, H
DOI：
10.1152/ajpcell.1998.274.2.c531
发表时间：
1998-02-01
影响因子：
5.5
作者：
Smolen, P;Baxter, DA;Byrne, JH
通讯作者：
Byrne, JH
影响因子：
3.4
作者：
Song, Hao;Smolen, Paul;Byrne, John H.
通讯作者：
Byrne, John H.