Preparation and In Vitro Release Behaviors of Paclitaxel-Loaded Pluronic F87/Poly(Lactic Acid) Nanoparticle
Preparation and In Vitro Release Behaviors of Paclitaxel-Loaded Pluronic F87/Poly(Lactic Acid) Nanoparticle
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紫杉醇Pluronic F87/聚乳酸纳米粒的制备及体外释放行为
DOI：
10.4028/www.scientific.net/amr.989-994.102
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Y. P. Li
中科院分区：
文献类型：
--
作者：
Zi;Y. Huang;X. Xiong;Y. Gong;Y. P. Li
采用本体聚合法合成了Pluronic F87/聚乳酸嵌段共聚物（PLA-F87-PLA）。采用透析法制备紫杉醇PLA-F87-PLA纳米粒。通过UV测定负载效率。结果表明，PLA-F87-PLA纳米粒对紫杉醇的负载率为69%。采用高效液相色谱法研究了紫杉醇PLA-F87-PLA纳米粒的体外释药行为。体外释放行为表现为先快速释放后缓慢释放。MTT法检测纳米粒的生物相容性。载紫杉醇的PLA-F87-PLA纳米粒的活力低于游离紫杉醇。结果表明PLA-F87-PLA共聚物具有良好的生物相容性。
Pluronic F87/Poly (lactic acid) block copolymer (PLA-F87-PLA) was synthesized by bulk polymerization. Paclitaxel-loaded PLA-F87-PLA nanoparcticles were prepared by a dialysis method. The loading efficiency was determined by UV. The results showed that the loading efficiency of paclitaxel for PLA-F87-PLA nanoparticles was 69%. In vitro release behavior of paclitaxel-loaded PLA-F87-PLA nanoparticles was studied by HPLC. In vitro release behavior showed an initial rapid release followed by a slow release. The biocompatibility of nanoparticles was measured by MTT. The viability of paclitaxel-loaded PLA-F87-PLA nanoparticles was less than that of free paclitaxel. The results indicated that PLA-F87-PLA copolymer has good biocompatibility.
影响因子：
10.8
作者：
Marin, A;Sun, H;Rapoport, NY
通讯作者：
Rapoport, NY