Hyperhomocyst(e)inaemia: an independent risk factor for intermittent claudication
Hyperhomocyst(e)inaemia: an independent risk factor for intermittent claudication
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高同型半胱氨酸血症：间歇性跛行的独立危险因素
DOI：
10.1111/j.1365-2796.1992.tb00535.x
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发表时间：
1992
影响因子：
11.1
通讯作者：
A. Olsson
中科院分区：
文献类型：
--
作者：
J. Mölgaard;M. Malinow;C. Lassvik;A. Holm;B. Upson;A. Olsson
抽象的。本研究的目的是检验高同型半胱氨酸血症作为间歇性跛行 (IC) 危险因素的问题，独立于外周动脉粥样硬化疾病的其他重要危险因素，如吸烟、高血压、糖尿病、高胆固醇血症、高甘油三酯血症、低水平高密度脂蛋白 (HDL) 胆固醇和年龄。研究人群是从瑞典林雪平县的一项流行病学研究中招募的，其中所有中年男性（n = 15253，45-69 岁）都接受了 IC 筛查。随机选择了 78 名经验证 IC 的受试者和 98 名性别和年龄匹配的健康对照者。 IC受试者的血浆同型半胱氨酸水平（包括游离形式和结合形式的同型半胱氨酸及其二硫化物氧化产物、同型半胱氨酸和同型半胱氨酸-半胱氨酸混合二硫化物）显着高于对照组（13.80 ± 3.21 μmol l−1）（16.74 ± 5.45 μmol l−1，平均值±SD，P = 0.0002）， 23% 的跛行者高于对照的 95%。逐步逻辑回归分析显示，血浆同型半胱氨酸的差异与上述其他危险因素无关。此外，跛行者血浆同型半胱氨酸升高主要局限于血清叶酸水平<11.0 nmol l−1的受试者。结果表明，患有高同型半胱氨酸血症的 IC 受试者应尝试补充叶酸。
Abstract. The aim of this study was to test the question of hyperhomocyst(e)inaemia as a risk factor for intermittent claudication (IC) independent of other important risk factors for peripheral atherosclerotic disease, such as smoking, hypertension, diabetes mellitus, hypercholesterolaemia, hypertriglyceridaemia, low levels of high‐density‐lipoprotein (HDL) cholesterol and age. The study population was recruited from an epidemiological study in LinkÖping County, Sweden, where all middle‐aged men (n = 15253, 45–69 years of age) were screened for IC. Seventy‐eight subjects with verified IC and 98 healthy sex‐ and age‐matched controls were randomly selected. Plasma levels of homocyst(e)ine (including the sum of free and bound forms of homocysteine and their disulphide oxidation products, homocystine, and homocysteine‐cysteine mixed disulphide) were significantly higher (16.74 ± 5.45 μmol l−1, mean value ± SD, P = 0.0002) in IC subjects than in controls (13.80 ± 3.21 μmol l−1), with 23% of the claudicants above the 95th percentile for controls. Stepwise logistic regression analysis revealed that the difference in plasma homocyst(e)ine was independent of the other above‐mentioned risk factors. Moreover, the elevation of plasma homocyst(e)ine in claudicants was mainly confined to subjects with serum folate levels of < 11.0 nmol l−1. The results suggest that folic acid supplementation should be tried in IC subjects with hyperhomocyst(e)inaemia.
硫醇化合物对低密度脂蛋白的氧化导致其被乙酰 LDL 受体识别。
DOI：
10.1016/0005-2760(87)90139-1
发表时间：
1987
期刊：
Biochimica et biophysica acta
影响因子：
--
作者：
Parthasarathy,S
通讯作者：
Parthasarathy,S
影响因子：
37.8
作者：
MALINOW, MR;KANG, SS;UPSON, B
通讯作者：
UPSON, B