Zebrafish mutagenesis yields eye morphological mutants with retinal and lens defects

Zebrafish mutagenesis yields eye morphological mutants with retinal and lens defects
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斑马鱼诱变产生具有视网膜和晶状体缺陷的眼睛形态突变体

DOI:
10.1016/s0042-6989(01)00261-9
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发表时间:
2002
期刊:
影响因子:
1.8
通讯作者:
D. Hyde
D. Hyde
中科院分区:
心理学3区
文献类型:
--
作者:
T. Vihtelic;D. Hyde

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A chemical mutagenesis to identify zebrafish eye morphological mutants was performed by screening F3larvae at 5 and 7 days post-fertilization (dpf) for changes in eye or pupil size. Based on histological analysis, four different phenotypic classes were obtained. The two Class I and three Class II mutants are all characterized by small eyes and exhibit defects in early retinal development or unregulated cell death, respectively. The single Class III mutant has reduced ocular pigmentation. The three Class IV mutants display defects in the ocular lens, including one mutant line with normal sized eyes and pupils that develops lens opacity at 7 dpf.
DOI: 10.1073/pnas.92.23.10545
发表时间: 1995-11-07
影响因子: 11.1
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BROCKERHOFF, SE;HURLEY, JB;DOWLING, JE
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DOI: 10.1242/dev.126.17.3757
发表时间: 1999
期刊: Development (Cambridge, England)
影响因子: --
作者:
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通讯作者: Raible,DW