Susceptibility to Memory Interference Effects following Frontal Lobe Damage: Findings from Tests of Paired-Associate Learning
Susceptibility to Memory Interference Effects following Frontal Lobe Damage: Findings from Tests of Paired-Associate Learning
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额叶损伤后对记忆干扰效应的易感性：配对联想学习测试的结果
DOI：
10.1162/jocn.1995.7.2.144
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发表时间：
1995
影响因子：
3.2
通讯作者：
R. Knight
中科院分区：
文献类型：
--
作者：
A. Shimamura;P. Jurica;Jennifer A. Mangels;Felick B. Gershberg;R. Knight
额叶损伤的患者进行配对联想学习测试，其中提示和反应词被操纵以增加两个研究列表之间的干扰。在配对关联学习的一个测试（AB-AC测试）中，在一个列表中使用的提示词在第二列表中重复，但是与不同的响应词相关联（例如，狮子猎人，狮子马戏团）。在另一个测试（AB-ABr测试）中，一个列表中使用的单词在第二个列表中重复，但重新排列以形成新的对。与对照组相比，额叶损伤的患者表现出不成比例的损害第二列表的学习作为干扰效应的结果。特别是，在第二个列表的初始试验期间，患者表现出最差的表现，在该试验中，来自第一个列表的干扰效果将是最明显的。这些研究结果表明，在线控制无关或竞争的记忆协会被破坏后额叶病变。这种中断可能表明门控或过滤机制受损，不仅影响记忆功能，还影响其他认知功能。
Patients with frontal lobe lesions were adminstered tests of paired-associate learning in which cue and response words are manipulated to increase interference across two study lists. In one test of paired-associate learning (AB-AC test), cue words used in one list are repeated in a second list but are associated with different response words (e.g., LION-HUNTER, LION-CIRCUS). In another test (AB-ABr test), words used in one list are repeated in a second list but are rearranged to form new pairs. Compared to control subjects, patients with frontal lobe lesions exhibited disproportionate impairment of second-list learning as a result of interference effects. In particular, patients exhibited the poorest performance during the initial trial of the second list, a trial in which interference effects from the first list would be most apparent. These findings suggest that the on-line control of irrelevant or competing memory associations is disrupted following frontal lobe lesions. This disruption may be indicative of an impaired gating or filtering mechanism that affects not only memory function but other cognitive function as well.
影响因子：
1.9
作者：
J. Janowsky;A. Shimamura;M. Kritchevsky;L. Squire
通讯作者：
J. Janowsky;A. Shimamura;M. Kritchevsky;L. Squire