Impact of Inflammatory Cytokines on Effector and Memory CD8+ T Cells.
Impact of Inflammatory Cytokines on Effector and Memory CD8+ T Cells.
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DOI：
10.3389/fimmu.2014.00295
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发表时间：
2014
影响因子：
7.3
通讯作者：
Harty JT
中科院分区：
文献类型：
--
作者：
Kim MT;Harty JT
长期以来，人们已经认识到炎性细胞因子可以产生有效的APC，从而引发强大的T细胞应答以实现保护性免疫。然而，炎症细胞因子信号直接对T细胞的影响最近才被认识到。尽管仍有许多有待了解，但CD 8 T细胞领域在理解炎症细胞因子在整个CD 8 T细胞应答中的作用方面取得了相当大的进展。关键发现首先将IL-12和I型干扰素鉴定为“信号3”细胞因子，强调了它们在产生最佳CD 8 T细胞应答中的重要性。单独的研究揭示了另一种炎性细胞因子IL-15在记忆性CD 8 T细胞维持中起关键作用。这些早期研究强调了CD 8 T细胞的潜在调节因子，但无法提供这些炎性细胞因子如何增强CD 8 T细胞介导的免疫力的机制见解。在这里，我们描述了我们实验室在优化效应和记忆CD 8 T细胞数量和功能方面所取得的关于“信号3”细胞因子和IL-15的作用的机制进展。此外，我们评估了细胞因子（如TGF-β）在最近描述的常驻记忆CD 8 T细胞群产生中的作用的初步进展。
Inflammatory cytokines have long been recognized to produce potent APCs to elicit robust T cell responses for protective immunity. The impact of inflammatory cytokine signaling directly on T cells, however, has only recently been appreciated. Although much remains to be learned, the CD8 T cell field has made considerable strides in understanding the effects of inflammatory cytokines throughout the CD8 T cell response. Key findings first identified IL-12 and type I interferons as “signal 3” cytokines, emphasizing their importance in generating optimal CD8 T cell responses. Separate investigations revealed another inflammatory cytokine, IL-15, to play a critical role in memory CD8 T cell maintenance. These early studies highlighted potential regulators of CD8 T cells, but were unable to provide mechanistic insight into how these inflammatory cytokines enhanced CD8 T cell-mediated immunity. Here, we describe the mechanistic advances that have been made in our lab regarding the role of “signal 3” cytokines and IL-15 in optimizing effector and memory CD8 T cell number and function. Furthermore, we assess initial progress on the role of cytokines, such as TGF-β, in generation of recently described resident memory CD8 T cell populations.
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影响因子：
7
作者：
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通讯作者：
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影响因子：
15.3
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