Distinct metabolomic signatures are associated with longevity in humans.
Distinct metabolomic signatures are associated with longevity in humans.
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DOI：
10.1038/ncomms7791
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发表时间：
2015-04-13
影响因子：
16.6
通讯作者：
Wang, Thomas J.
中科院分区：
文献类型：
--
作者：
Cheng, Susan;Larson, Martin G.;McCabe, Elizabeth L.;Murabito, Joanne M.;Rhee, Eugene P.;Ho, Jennifer E.;Jacques, Paul F.;Ghorbani, Anahita;Magnusson, Martin;Souza, Amanda L.;Deik, Amy A.;Pierce, Kerry A.;Bullock, Kevin;O'Donnell, Christopher J.;Melander, Olle;Clish, Clary B.;Vasan, Ramachandran S.;Gerszten, Robert E.;Wang, Thomas J.
在实验模型中，新陈代谢的改变会影响寿命，但缺乏人体数据。在这里，我们使用液相色谱/质谱法对 217 种血浆代谢物进行定量，并在一大群男性和女性中检查它们与寿命的关系。在对 647 名个体进行了长达 20 年的跟踪调查后，柠檬酸循环中间体异柠檬酸和胆汁酸牛磺胆酸盐的浓度较高，与长寿（定义为达到 80 岁）的较低几率相关。在拥有可用代谢数据的 2,327 名个体的更大队列中，较高浓度的异柠檬酸盐（而非牛磺胆酸盐）也与基线时较差的心血管健康状况以及未来心血管疾病和死亡的风险相关。所鉴定的代谢物均与癌症风险无关。我们的研究结果表明，人类长寿的一些（但不是全部）代谢途径取决于改变两种最常见死因的风险。
Alterations in metabolism influence lifespan in experimental models, but data in humans are lacking. Here we use liquid chromatography/mass spectrometry to quantify 217 plasma metabolites and examine their relation to longevity in a large cohort of men and women. In 647 individuals followed for up to 20 years, higher concentrations of the citric acid cycle intermediate, isocitrate, and the bile acid, taurocholate, are associated with lower odds of longevity, defined as attaining 80 years of age. In a larger cohort of 2,327 individuals with metabolite data available, higher concentrations of isocitrate but not taurocholate are also associated with worse cardiovascular health at baseline, as well as risk of future cardiovascular disease and death. None of the metabolites identified are associated with cancer risk. Our findings suggest that some, but not all, metabolic pathways to human longevity are dependent on modifying risk for the two most common causes of death.
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作者：
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发表时间：
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DOI：
10.1016/j.bbrc.2011.02.136
发表时间：
2011-04-01
影响因子：
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作者：
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通讯作者：
Mukai, Yukio