Adjustable viscoelasticity allows for efficient collective cell migration.
Adjustable viscoelasticity allows for efficient collective cell migration.
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DOI：
10.1016/j.semcdb.2018.05.027
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发表时间：
2019-09
影响因子：
7.3
通讯作者：
Mayor R
中科院分区：
文献类型：
--
作者：
Barriga EH;Mayor R
细胞迁移在胚胎形态发生、伤口愈合、再生等广泛的生物学过程中是必不可少的，在癌症等病理条件下也是如此。在这种情况下，细胞需要作为单独的实体或高度协调的集体迁移，这两者都需要细胞对来自其环境的分子和机械线索做出反应。然而，虽然化学信号在细胞迁移中的作用已被较好地了解，但组织力学对细胞迁移的作用才刚刚开始研究。最近的研究表明，迁移细胞簇内粘弹性的动态调节及其周围组织的足够弹性特性，对于允许细胞在体内有效地集体迁移是必不可少的。在这篇综述中，我们重点介绍了粘弹性在各种细胞系统中控制集体细胞迁移的作用，并简要地提到了单细胞迁移的一些方面。我们的目标是提供关于集体迁移的细胞群及其周围的粘弹性如何被调节以确保正确的形态发生、伤口愈合和转移的细节。最后，我们试图证明环境粘弹性在迁移的团簇中触发分子变化，并且这些新的分子设置改变了团簇的粘弹性，最终允许它们跨越具有挑战性的微环境的几何形状迁移。
Cell migration is essential for a wide range of biological processes such as embryo morphogenesis, wound healing, regeneration, and also in pathological conditions, such as cancer. In such contexts, cells are required to migrate as individual entities or as highly coordinated collectives, both of which requiring cells to respond to molecular and mechanical cues from their environment. However, whilst the function of chemical cues in cell migration is comparatively well understood, the role of tissue mechanics on cell migration is just starting to be studied. Recent studies suggest that the dynamic tuning of the viscoelasticity within a migratory cluster of cells, and the adequate elastic properties of its surrounding tissues, are essential to allow efficient collective cell migration in vivo. In this review we focus on the role of viscoelasticity in the control of collective cell migration in various cellular systems, mentioning briefly some aspects of single cell migration. We aim to provide details on how viscoelasticity of collectively migrating groups of cells and their surroundings is adjusted to ensure correct morphogenesis, wound healing, and metastasis. Finally, we attempt to show that environmental viscoelasticity triggers molecular changes within migrating clusters and that these new molecular setups modify clusters’ viscoelasticity, ultimately allowing them to migrate across the challenging geometries of their microenvironment.
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影响因子：
19.6
作者：
Brugués A;Anon E;Conte V;Veldhuis JH;Gupta M;Colombelli J;Muñoz JJ;Brodland GW;Ladoux B;Trepat X
通讯作者：
Trepat X
影响因子：
64.8
作者：
Barriga EH;Franze K;Charras G;Mayor R
通讯作者：
Mayor R
DOI：
10.1083/jcb.201009141
发表时间：
2011-03-21
期刊：
The Journal of cell biology
影响因子：
--
作者：
Baum B;Georgiou M
通讯作者：
Georgiou M
DOI：
10.1111/j.1749-6632.1968.tb20280.x
发表时间：
1968-01-01
影响因子：
5.2
作者：
Burstein, A H;Frankel, V H
通讯作者：
Frankel, V H
DOI：
10.1073/pnas.1522656113
发表时间：
2016-04-12
影响因子：
11.1
作者：
Cai, Danfeng;Dai, Wei;Montell, Denise J.
通讯作者：
Montell, Denise J.