Anterior cingulate activity to monetary loss and basal ganglia activity to monetary gain uniquely contribute to the feedback negativity.
Anterior cingulate activity to monetary loss and basal ganglia activity to monetary gain uniquely contribute to the feedback negativity.
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DOI：
10.1016/j.clinph.2014.08.025
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发表时间：
2015-07
期刊：
影响因子：
--
通讯作者：
Proudfit GH
中科院分区：
文献类型：
--
作者：
Foti D;Weinberg A;Bernat EM;Proudfit GH
反馈负性 (FN) 是一种与事件相关的电位，可区分不利结果和有利结果。尽管人们认为 FN 反映了前扣带皮层内与错误相关的活动，但最近的研究表明，FN 也可能反映了与基底神经节相关的奖励相关活动。迄今为止，尚不清楚如何调和这些相互冲突的观点。我们通过应用时频分析来分解 FN，以隔离货币损失和收益特有的活动。 FN 是在实验室赌博任务中从 84 个人身上记录下来的。不可预测的结果引发了 FN 的两个信号：theta 活动（4-7 Hz）在货币损失后增加，而 delta 活动（< 3 Hz）在货币收益后增加。可预测的结果会引发 delta 活动，但不会引发 theta 活动。源分析揭示了不同的发生器，与损失相关的 θ 位于前扣带皮层，与增益相关的 delta 位于纹状体中的一个可能的源。抑郁、焦虑和压力反应的症状与增益相关增量的减弱特别相关。 FN 可能是与损失和增益相关的神经活动的复合体，反映了奖励处理的不同方面。与增益相关的δ活动可能提供有关重度抑郁症和其他内化精神病理学中的奖赏功能障碍的独特信息。
The feedback negativity (FN) is an event-related potential that differentiates unfavorable versus favorable outcomes. Although thought to reflect error-related activity within the anterior cingulate cortex, recent work indicates the FN may also reflect reward-related activity that has been linked to the basal ganglia. To date, it remains unclear how to reconcile these conflicting perspectives. We decomposed the FN by applying time-frequency analysis to isolate activity unique to monetary losses and gains. The FN was recorded from 84 individuals during a laboratory gambling task. Two signals contributed to the FN elicited by unpredictable outcomes: theta activity (4-7 Hz) was increased following monetary loss, and delta activity (< 3 Hz) was increased following monetary gain. Predictable outcomes elicited delta but not theta activity. Source analysis revealed distinct generators, with loss-related theta localized to the anterior cingulate cortex and gain-related delta to a possible source in the striatum. Symptoms of depression, anxiety, and stress reactivity were specifically associated with blunted gain-related delta. The FN may be a composite of loss- and gain-related neural activity, reflecting distinct facets of reward processing. Gain-related delta activity may provide unique information about reward dysfunction in major depression and other internalizing psychopathology.
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影响因子：
3.7
作者：
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通讯作者：
Dien, Joseph
DOI：
10.1023/a:1011095624717
发表时间：
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影响因子：
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