Neural response to reward and depressive symptoms in late childhood to early adolescence.
Neural response to reward and depressive symptoms in late childhood to early adolescence.
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DOI：
10.1016/j.biopsycho.2011.10.004
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发表时间：
2012-01
影响因子：
2.6
通讯作者：
Hajcak, Greg
中科院分区：
文献类型：
--
作者：
Bress, Jennifer N.;Smith, Ezra;Foti, Dan;Klein, Daniel N.;Hajcak, Greg
抑郁症是一个主要的公共卫生问题，从童年晚期到青春期早期是抑郁症状发展的关键时期。在成年人中，抑郁和抑郁症状与反馈负性（FN）的减少有关，FN是由反馈引起的ERP成分，表明奖励与损失。目前的研究试图将这些发现扩展到64名8至13岁的儿童样本中，并检查FN的发育差异。与先前在成人中的研究一致，在整个样本中，较高的抑郁症状评分与钝化的FN相关。当对损失和收益的反应分别进行检查时，只有对金钱收益的反应减少与抑郁症状的增加有关。在目前的研究中，绝大多数儿童处于青春期前，FN与年龄和青春期发育无关。FN可能是一种理想的生物标志物，用于研究儿童在青春期过渡期间出现的奖励敏感性和抑郁症的变化。
Depression is a major public health concern, and the period from late childhood through early adolescence is a critical time in the development of depressive symptoms. In adults, depression and depressive symptoms are associated with a reduction in the feedback negativity (FN), an ERP component elicited by feedback indicating rewards versus losses. The current study sought to extend these findings to a sample of 64 children aged 8 to 13, and to examine developmental differences in the FN. Consistent with previous work in adults, higher depressive symptom scores were associated with a blunted FN across the sample. When responses to losses and gains were examined separately, only reduction in the response to monetary gain was associated with increased depressive symptoms. In the current study, the vast majority of children were pre-pubertal, and the FN was unrelated to both age and pubertal development. The FN may be an ideal biomarker for studying changes in reward sensitivity and depression that emerge as children transition through puberty.
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