Gut Bacteria Selectively Altered by Sennoside A Alleviate Type 2 Diabetes and Obesity Traits
Gut Bacteria Selectively Altered by Sennoside A Alleviate Type 2 Diabetes and Obesity Traits
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番泻苷 A 选择性改变肠道细菌可缓解 2 型糖尿病和肥胖特征
DOI：
10.1155/2020/2375676
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发表时间：
2020-06
期刊：
影响因子：
--
通讯作者：
Zhiguang Sun
中科院分区：
文献类型：
--
作者：
Zhonghong Wei;Peiliang Shen;Peng Cheng;Yin Lu;Aiyun Wang;Zhiguang Sun
摘要：越来越多的证据表明，肠道微生物区系在脂肪炎症和糖尿病的发生和延长中起着重要作用。番泻苷A是大黄的主要活性成分，广泛用于便秘，是一种蒽类泻药(如番泻叶)。在此，我们提出肥胖小鼠肠道微生物区系的结构改变可能参与了2型糖尿病(T2D)的发病机制的假说，番泻苷A可以改善T2D的发病。我们研究了番泻苷A对db/db小鼠肥胖、胰岛素抵抗、宿主炎症和肠漏表型的影响。水平粪便微生物区系移植(FMT)证实肠道微生物区系在番泻苷A治疗后T2D小鼠的各项指标改善中的关键作用。结果，我们发现番泻苷A给药显著改善了T2D小鼠的指数和肥胖相关特征，包括血糖水平、体重、脂代谢紊乱和胰岛素抵抗。Db/db小鼠在T2D发病过程中肠道微生物区系变化迅速，证实了肠道微生物区系参与T2D发病机制的假说。番泻苷A改变了肠道微生物组成，可能介导了T2D缓解中的抗肿瘤作用。番泻苷A还通过肠道微生物区系改变减轻了炎症，并增加了基因缺陷小鼠回肠紧密连接蛋白的含量。FMT降低血糖，改善胰岛素抵抗，证实番泻苷A可能通过改变肠道微生物区系发挥抗肿瘤作用。本条所研究的化合物。本文研究的化合物包括番泻苷A(PubChem CID：73111)和盐酸二甲双胍(PubChem CID：14219)。
Abstract.Accumulating evidences implicate that gut microbiota play an important role in the onset and prolongation of fat inflammation and diabetes. Sennoside A, the main active ingredient of Rhizoma Rhei (rhubarb), is widely used for constipation as a kind of anthranoid laxative (e.g., senna). Here, we put forward the hypothesis that the structural alteration of gut microbiota in obesity mice may be involved in the pathogenesis of type 2 diabetes (T2D) which may be ameliorated by Sennoside A. We investigated the appearance of obesity, insulin resistance, host inflammation, and leaky gut phenotype with or without Sennoside A in db/db mice. Horizontal fecal microbiota transplantation (FMT) was used to confirm the critical roles of gut microbiota in the amelioration of the indices in T2D mice after Sennoside A treatment. As a result, we found that Sennoside A administration markedly improved the indices in T2D mice and obesity-related traits including blood glucose level, body weight, lipid metabolism disorder, and insulin resistance. The gut microbiota changed quickly during the onset of T2D in db/db mice, which confirmed the hypothesis that gut microbiota was involved in the pathogenesis of T2D. Sennoside A altered gut microbial composition which might mediate the antiobesogenic effects in T2D remission. Sennoside A also reduced inflammation and increased tight junction proteins in the ileum in gene-deficient mice via gut microbiota alteration. FMT lowered the blood glucose level and improved insulin resistance, corroborating that Sennoside A perhaps exerted its antiobesogenic effects through gut microbiota alteration. Chemical Compounds Studied in This Article. Compounds studied in this article include Sennoside A (PubChem CID: 73111) and metformin hydrochloride (PubChem CID: 14219).
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影响因子：
7.7
作者：
Cani, Patrice D.;Amar, Jacques;Burcelin, Remy
通讯作者：
Burcelin, Remy
影响因子：
30.3
作者：
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DOI：
10.1007/978-1-61779-430-8_27
发表时间：
2012
期刊：
Methods in molecular biology (Clifton, N.J.)
影响因子：
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作者：
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通讯作者：
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巨噬细胞的局部扩散有助于与肥胖相关的脂肪组织炎症。
影响因子：
29
作者：
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通讯作者：
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DOI：
10.1126/science.1241214
发表时间：
2013-09-06
期刊：
Science (New York, N.Y.)
影响因子：
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作者：
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通讯作者：
Gordon JI