Gut microbiota from twins discordant for obesity modulate metabolism in mice.
Gut microbiota from twins discordant for obesity modulate metabolism in mice.
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DOI：
10.1126/science.1241214
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发表时间：
2013-09-06
期刊：
影响因子：
--
通讯作者：
Gordon JI
中科院分区：
文献类型：
--
作者：
Ridaura VK;Faith JJ;Rey FE;Cheng J;Duncan AE;Kau AL;Griffin NW;Lombard V;Henrissat B;Bain JR;Muehlbauer MJ;Ilkayeva O;Semenkovich CF;Funai K;Hayashi DK;Lyle BJ;Martini MC;Ursell LK;Clemente JC;Van Treuren W;Walters WA;Knight R;Newgard CB;Heath AC;Gordon JI
特定肠道微生物在塑造身体成分方面的作用尚不清楚。我们将不利于肥胖的成年雌性双胞胎的粪便微生物群移植到喂食低脂小鼠食物和代表不同水平饱和脂肪的饮食以及典型的美国水果和蔬菜消费的无菌小鼠身上。增加的全身和脂肪质量以及肥胖相关的代谢表型可通过未培养的粪便群落及其相应的粪便细菌培养样本传播。携带肥胖双胞胎微生物群(Ob)的小鼠与含有瘦小双胞胎微生物群(Ln)的小鼠共居可防止体重增加和肥胖相关代谢表型在Ob笼子中的发展。救援与类杆菌的特定成员从Ln微生物群入侵Ob微生物群相关，并且依赖于饮食。这些发现揭示了饮食与微生物群相互作用的可传播、快速和可改变的影响。
The role of specific gut microbes in shaping body composition remains unclear. We transplanted fecal microbiota from adult female twin pairs discordant for obesity into germ-free mice fed low-fat mouse chow, as well as diets representing different levels of saturated fat and fruit and vegetable consumption typical of the USA. Increased total body and fat mass, as well as obesity-associated metabolic phenotypes were transmissible with uncultured fecal communities, and with their corresponding fecal bacterial culture collections. Co-housing mice harboring an obese twin’s microbiota (Ob) with mice containing the lean co-twin’s microbiota (Ln) prevented the development of increased body mass and obesity-associated metabolic phenotypes in Ob cagemates. Rescue correlated with invasion of specific members of Bacteroidetes from the Ln microbiota into Ob microbiota, and was diet-dependent. These findings reveal transmissible, rapid and modifiable effects of diet-by-microbiota interactions.
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DOI：
10.1073/pnas.1002601107
发表时间：
2010-06-29
影响因子：
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通讯作者：
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