Extracellular Vesicles as Therapeutic Tools for the Treatment of Chronic Wounds.
Extracellular Vesicles as Therapeutic Tools for the Treatment of Chronic Wounds.
复制标题
细胞外囊泡作为治疗慢性伤口的治疗工具。
DOI：
10.3390/pharmaceutics13101543
复制
发表时间：
2021-09-23
期刊：
影响因子：
5.4
通讯作者：
Badiavas EV
中科院分区：
文献类型：
--
作者：
Bray ER;Oropallo AR;Grande DA;Kirsner RS;Badiavas EV
当皮肤伤口愈合的有序过程被延迟或破坏时，就会形成慢性伤口。慢性伤口的发展与个人和医疗保健系统的严重发病率和经济负担相关。因此，需要新的治疗方式来解决这种严重的情况。间充质干细胞（MSC）促进皮肤修复，但由于技术挑战，其临床应用受到限制。细胞外囊泡 (EV) 是细胞释放的颗粒，携带生物活性分子（脂质、蛋白质和核酸）并调节细胞间通讯。 EV（外泌体、微泡和凋亡小体）介导 MSC 的关键治疗作用。在这篇综述中，我们研究了确定电动汽车在伤口愈合中作用的实验数据。然后，我们探索设计电动汽车作为靶向药物输送系统的技术，以及如何将电动汽车纳入生物材料中以生产个性化的伤口敷料。最后，我们讨论了电动汽车作为伤口护理治疗剂的临床应用状况。
Chronic wounds develop when the orderly process of cutaneous wound healing is delayed or disrupted. Development of a chronic wound is associated with significant morbidity and financial burden to the individual and health-care system. Therefore, new therapeutic modalities are needed to address this serious condition. Mesenchymal stem cells (MSCs) promote skin repair, but their clinical use has been limited due to technical challenges. Extracellular vesicles (EVs) are particles released by cells that carry bioactive molecules (lipids, proteins, and nucleic acids) and regulate intercellular communication. EVs (exosomes, microvesicles, and apoptotic bodies) mediate key therapeutic effects of MSCs. In this review we examine the experimental data establishing a role for EVs in wound healing. Then, we explore techniques for designing EVs to function as a targeted drug delivery system and how EVs can be incorporated into biomaterials to produce a personalized wound dressing. Finally, we discuss the status of clinically deploying EVs as a therapeutic agent in wound care.
登录
查看更多内容
影响因子：
23.9
作者：
Caplan AI;Correa D
通讯作者：
Correa D
DOI：
10.1111/j.1365-2362.2004.01291.x
发表时间：
2004-01-01
影响因子：
5.5
作者：
Advani, A;Marshall, SM;Thomas, TH
通讯作者：
Thomas, TH
影响因子：
5.9
作者：
Ambattu LA;Ramesan S;Dekiwadia C;Hanssen E;Li H;Yeo LY
通讯作者：
Yeo LY
影响因子：
2.6
作者：
Bartholomew, A;Sturgeon, C;Hoffman, R
通讯作者：
Hoffman, R
影响因子：
3.6
作者：
Broughton, George 2nd;Janis, Jeffrey E;Attinger, Christopher E
通讯作者：
Attinger, Christopher E