The Role of Immunogenetics in COVID-19.
The Role of Immunogenetics in COVID-19.
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DOI：
10.3390/ijms22052636
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发表时间：
2021-03-05
影响因子：
5.6
通讯作者：
Aiello A
中科院分区：
文献类型：
--
作者：
Pojero F;Candore G;Caruso C;Di Bona D;Groneberg DA;Ligotti ME;Accardi G;Aiello A
2019年冠状病毒病（COVID-19）由SARS-CoV-2引起，可能以各种临床表现出现，从无症状的疾病到与细胞因子风暴、多器官和呼吸衰竭相关的危及生命的疾病。这种变异性背后的分子机制仍在研究中。一些实验证据表明，影响免疫反应的发生、维持和消退的遗传变异可能是预测疾病演变的基础。识别COVID-19中免疫系统反应性和功能背后的遗传变异可能有助于制定个性化治疗策略。在狂热地寻找普遍共享的治疗计划时，那些在其他疾病/模型中常见的遗传变异也可能有助于解决未来在药物再利用方面的研究。在本文中，我们讨论了免疫遗传学在确定SARS-CoV-2感染的易感性和历史中的作用的最新进展。我们建议对现有数据进行叙述性综述，推测我们从其他病毒感染和免疫衰老中吸取的教训，并讨论应该深化哪些方面的研究，以提高我们对宿主遗传变异如何影响COVID-19患者结局的认识。
Coronavirus disease 2019 (COVID-19) is induced by SARS-CoV-2 and may arise as a variety of clinical manifestations, ranging from an asymptomatic condition to a life-threatening disease associated with cytokine storm, multiorgan and respiratory failure. The molecular mechanism behind such variability is still under investigation. Several pieces of experimental evidence suggest that genetic variants influencing the onset, maintenance and resolution of the immune response may be fundamental in predicting the evolution of the disease. The identification of genetic variants behind immune system reactivity and function in COVID-19 may help in the elaboration of personalized therapeutic strategies. In the frenetic look for universally shared treatment plans, those genetic variants that are common to other diseases/models may also help in addressing future research in terms of drug repurposing. In this paper, we discuss the most recent updates about the role of immunogenetics in determining the susceptibility to and the history of SARS-CoV-2 infection. We propose a narrative review of available data, speculating about lessons that we have learnt from other viral infections and immunosenescence, and discussing what kind of aspects of research should be deepened in order to improve our knowledge of how host genetic variability impacts the outcome for COVID-19 patients.
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影响因子：
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作者：
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DOI：
10.1016/j.jaci.2020.11.006
发表时间：
2021-03
期刊：
The Journal of allergy and clinical immunology
影响因子：
--
作者：
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通讯作者：
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影响因子：
3.7
作者：
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影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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