The COSMIC (Catalogue of Somatic Mutations in Cancer) database and website.

The COSMIC (Catalogue of Somatic Mutations in Cancer) database and website.
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宇宙(癌症中的体细胞突变目录)数据库和网站。

DOI:
10.1038/sj.bjc.6601894
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发表时间:
2004-07-19
影响因子:
8.8
通讯作者:
Wooster, R
Wooster, R
中科院分区:
医学1区
文献类型:
--
作者:
Bamford, S;Dawson, E;Forbes, S;Clements, J;Pettett, R;Dogan, A;Flanagan, A;Teague, J;Futreal, PA;Stratton, MR;Wooster, R

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癌症基因突变的发现促进了我们对癌症的理解。这些结果散布在科学文献中,随着人类基因组序列的可用,这些结果将继续积累。已经开发了COSMIC(癌症体细胞突变目录)数据库和网站,以在单一位置存储体细胞突变数据,并显示与人类癌症相关的数据和其他信息。为了填充这一资源,目前已从科学文献中的报告中提取了四个基因BRAF、HRAS、KRAS2和NRAS的体细胞突变数据。目前,该数据库保存了66个 634样本的信息,共报告了10个 647突变。通过网页,可以查询这些数据,以数字或表格的形式显示,并以多种格式输出。COSMIC是一个正在进行的项目,将继续整理体细胞突变数据并通过网站发布。
The discovery of mutations in cancer genes has advanced our understanding of cancer. These results are dispersed across the scientific literature and with the availability of the human genome sequence will continue to accrue. The COSMIC (Catalogue of Somatic Mutations in Cancer) database and website have been developed to store somatic mutation data in a single location and display the data and other information related to human cancer. To populate this resource, data has currently been extracted from reports in the scientific literature for somatic mutations in four genes, BRAF, HRAS, KRAS2 and NRAS. At present, the database holds information on 66 634 samples and reports a total of 10 647 mutations. Through the web pages, these data can be queried, displayed as figures or tables and exported in a number of formats. COSMIC is an ongoing project that will continue to curate somatic mutation data and release it through the website.
DOI: 10.1093/nar/30.1.387
发表时间: 2002-01-01
影响因子: 14.9
作者:
Fredman, D;Siegfried, M;Brookes, AJ
通讯作者: Brookes, AJ
DOI: 10.1002/humu.10081
发表时间: 2002-01-01
期刊: HUMAN MUTATION
影响因子: 3.9
作者:
Olivier, M;Eeles, R;Hainaut, P
通讯作者: Hainaut, P
DOI: 10.1093/nar/gkh073
发表时间: 2004-01-01
影响因子: 14.9
作者:
Wheeler DL;Church DM;Edgar R;Federhen S;Helmberg W;Madden TL;Pontius JU;Schuler GD;Schriml LM;Sequeira E;Suzek TO;Tatusova TA;Wagner L
通讯作者: Wagner L
DOI: 10.1038/nrc1299
发表时间: 2004-03
期刊: Nature reviews. Cancer
影响因子: --
作者:
通讯作者: --
DOI: 10.1093/nar/gkg046
发表时间: 2003-01-01
影响因子: 14.9
作者:
Mulder, NJ;Apweiler, R;Zdobnov, EM
通讯作者: Zdobnov, EM