Stimulus-specific responses in innate immunity: Multilayered regulatory circuits.
Stimulus-specific responses in innate immunity: Multilayered regulatory circuits.
复制标题
先天免疫中的刺激特异性反应：多层调节回路。
DOI：
10.1016/j.immuni.2021.08.018
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发表时间：
2021-09-14
期刊：
影响因子：
32.4
通讯作者：
Hoffmann A
中科院分区：
文献类型：
--
作者：
Luecke S;Sheu KM;Hoffmann A
免疫前哨细胞启动对病原体和组织损伤的免疫应答，并且能够产生高度刺激特异性应答。对这种特异性机制的深入了解来自于对调控因子和生化途径的识别，以及对能够对信息进行组合和时间编码的信号传导回路的定义。在这里，我们回顾了多层的分子机制，刺激特异性基因表达的巨噬细胞。我们将炎症和抗病原体信号通路的组成部分分为五层调节控制，并讨论了确定每层信号特征的统一机制。在这种情况下，我们审查的机制，使组合和时间编码的信息，确定经常性的监管图案和原则，并提出战略整合实验和计算的方法对先天免疫信号特异性的理解。免疫前哨细胞能够对病原体或组织损伤做出高度特异性的反应。Hoffmann及其同事回顾了巨噬细胞中刺激特异性基因表达的机制，并提供了一个框架，用于分类调节控制层，并了解先天免疫中信号信息的时间和组合编码机制。
Immune sentinel cells initiate immune responses to pathogens and tissue injury and are capable of producing highly stimulus-specific responses. Insight into the mechanisms underlying such specificity has come from the identification of regulatory factors and biochemical pathways, as well as the definition of signaling circuits that enable combinatorial and temporal coding of information. Here we review the multi-layered molecular mechanisms that underlie stimulus-specific gene expression in macrophages. We categorize components of inflammatory and anti-pathogenic signaling pathways into five layers of regulatory control and discuss unifying mechanisms determining signaling characteristics at each layer. In this context, we review mechanisms that enable combinatorial and temporal encoding of information, identify recurring regulatory motifs and principles, and present strategies for integrating experimental and computational approaches towards the understanding of signaling specificity in innate immunity. Immune sentinel cells are capable of highly specific responses to pathogens or tissue injury. Hoffmann and colleagues review the mechanisms that underlie stimulus-specific gene expression in macrophages and provide a framework for categorizing layers of regulatory control and understanding the mechanisms that enable temporal and combinatorial encoding of signal information in innate immunity.
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影响因子：
4
作者：
Behar, Marcelo;Hoffmann, Alexander
通讯作者：
Hoffmann, Alexander
影响因子：
32.4
作者：
Adelaja A;Taylor B;Sheu KM;Liu Y;Luecke S;Hoffmann A
通讯作者：
Hoffmann A
影响因子：
9.8
作者：
Albeck JG;Burke JM;Spencer SL;Lauffenburger DA;Sorger PK
通讯作者：
Sorger PK
DOI：
10.1126/science.1179050
发表时间：
2009-10-09
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Amit I;Garber M;Chevrier N;Leite AP;Donner Y;Eisenhaure T;Guttman M;Grenier JK;Li W;Zuk O;Schubert LA;Birditt B;Shay T;Goren A;Zhang X;Smith Z;Deering R;McDonald RC;Cabili M;Bernstein BE;Rinn JL;Meissner A;Root DE;Hacohen N;Regev A
通讯作者：
Regev A
影响因子：
9.2
作者：
Bardwell, Lee
通讯作者：
Bardwell, Lee