Regional cortical thinning predicts worsening apathy and hallucinations across the Alzheimer disease spectrum.
Regional cortical thinning predicts worsening apathy and hallucinations across the Alzheimer disease spectrum.
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DOI：
10.1016/j.jagp.2013.03.006
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发表时间：
2014-11
影响因子：
7.2
通讯作者：
Marshall, Gad A.
中科院分区：
文献类型：
--
作者：
Donovan, Nancy J.;Wadsworth, Lauren P.;Lorius, Natacha;Locascio, Joseph J.;Rentz, Dorene M.;Johnson, Keith A.;Sperling, Reisa A.;Marshall, Gad A.
在包括临床正常老年人、轻度认知障碍和轻度AD痴呆的连续人群中，检查与冷漠和幻觉相关的皮质变薄和脑脊液（CSF）阿尔茨海默病（AD）生物标志物区域。横向和纵向研究。在北美的57个研究中心。812名社区居住志愿者; 413名参与CSF子研究。分析了来自阿尔茨海默病神经影像学倡议数据库的结构磁共振成像数据和淀粉样蛋白β 1-42、总tau和磷酸化tau的CSF浓度。在基线和3年以上使用神经精神病调查问卷测量冷漠和幻觉。使用一般线性模型和混合效应模型评价7个区域的基线皮质厚度、基线CSF生物标志物与基线和纵向冷漠和幻觉之间的关系。协变量包括诊断、性别、年龄、载脂蛋白E基因型、病前智力、记忆表现、处理速度、抗抑郁药使用和AD持续时间。减少基线颞下皮质厚度预测随着时间的推移冷漠增加，而减少边缘上皮质厚度预测随着时间的推移幻觉增加。基线时与皮质厚度无关。在横断面或纵向分析中，CSF生物标志物与冷漠或幻觉的严重程度无关。这些结果表明，更大的基线颞叶和顶叶萎缩与大型AD谱系队列中的冷漠和幻觉恶化相关，同时调整多个疾病相关变量。局部皮质神经退行性变可能导致AD患者的冷漠和幻觉的病理生理学及其不良后果。
To examine regions of cortical thinning and cerebrospinal fluid (CSF) Alzheimer’s disease (AD) biomarkers associated with apathy and hallucinations in a continuum of individuals including clinically normal elderly, mild cognitive impairment and mild AD dementia. Cross-sectional and longitudinal studies. 57 research sites across North America. 812 community dwelling volunteers; 413 participants in the CSF sub-study. Structural magnetic resonance imaging data and CSF concentrations of amyloid-β 1-42, total tau and phosphorylated tau derived from the Alzheimer’s Disease Neuroimaging Initiative database were analyzed. Apathy and hallucinations were measured at baseline and over 3 years using the Neuropsychiatric Inventory-Questionnaire. General linear models and mixed effects models were used to evaluate the relationships among baseline cortical thickness in 7 regions, baseline CSF biomarkers and apathy and hallucinations at baseline and longitudinally. Covariates included diagnosis, gender, age, Apolipoprotein E genotype, premorbid intelligence, memory performance, processing speed, antidepressant use, and AD duration. Reduced baseline inferior temporal cortical thickness was predictive of increasing apathy over time, while reduced supramarginal cortical thickness was predictive of increasing hallucinations over time. There was no association with cortical thickness at baseline. CSF biomarkers were not related to severity of apathy or hallucinations in cross-sectional or longitudinal analyses. These results suggest that greater baseline temporal and parietal atrophy is associated with worsening apathy and hallucinations in a large AD spectrum cohort, while adjusting for multiple disease-related variables. Localized cortical neurodegeneration may contribute to the pathophysiology of apathy and hallucinations and their adverse consequences in AD.
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影响因子：
--
作者：
Marshall, Gad A.;Monserratt, Lorena;Sultzer, David L.
通讯作者：
Sultzer, David L.
影响因子：
7.2
作者：
Kim, Jee Wook;Lee, Dong Young;Woo, Jong Inn
通讯作者：
Woo, Jong Inn
影响因子：
9.9
作者：
Bakkour, Akram;Morris, John C.;Dickerson, Bradford C.
通讯作者：
Dickerson, Bradford C.
影响因子：
3.6
作者：
NELSON, HE;OCONNELL, A
通讯作者：
OCONNELL, A
影响因子：
9.9
作者：
McDonald, C. R.;McEvoy, L. K.;Dale, A. M.
通讯作者：
Dale, A. M.