Screening and surveillance for second malignant neoplasms in adult survivors of childhood cancer: a report from the childhood cancer survivor study.
Screening and surveillance for second malignant neoplasms in adult survivors of childhood cancer: a report from the childhood cancer survivor study.
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DOI：
10.7326/0003-4819-153-7-201010050-00007
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发表时间：
2010-10-05
影响因子：
39.2
通讯作者：
Oeffinger KC
中科院分区：
文献类型：
--
作者：
Nathan PC;Ness KK;Mahoney MC;Li Z;Hudson MM;Ford JS;Landier W;Stovall M;Armstrong GT;Henderson TO;Robison LL;Oeffinger KC
儿童癌症幸存者可能在成年后发展为第二种恶性肿瘤，因此需要定期监测。检查平均罹患第二种恶性肿瘤风险的幸存者对人群癌症筛查指南的遵守情况，以及罹患第二种恶性肿瘤的高风险幸存者遵守癌症监测指南的情况。回顾性队列研究。儿童癌症幸存者研究(CCSS)是一项26中心的研究，研究对象是1970至1986年间确诊的儿童癌症长期幸存者。4,329名男性和4,018名女性儿童癌症幸存者完成了CCSS问卷，评估了对新癌症的筛查和监测。患者报告的乳房X光检查、巴氏涂片、结肠镜检查或皮肤检查的时间被归类为遵守美国预防服务工作组针对乳腺癌或宫颈癌中等风险幸存者的指南，或儿童肿瘤学组织针对因治疗而患乳腺癌、结直肠癌或皮肤癌的高风险幸存者的指南。在平均风险女性幸存者中，2743/3392(80.9%)报告在推荐期内进行了巴氏涂片，140/209(67.0%)报告在推荐期内进行了乳房X光检查。在高危幸存者中，女性推荐的乳房X光检查、结肠镜检查和完整皮肤检查的男女比例分别为241/522(46.2%)、91/794(11.5%)和1290/4850(26.6%)。数据均为自我报告。CCSS参与者是选定的幸存者群体，他们的依从性可能不代表所有儿童癌症幸存者。患有第二种恶性肿瘤的女性幸存者表现出合理的宫颈癌和乳腺癌筛查率。然而，在结肠癌、乳腺癌或皮肤癌风险最高的幸存者中，对新癌症的监测非常差，这表明幸存者和他们的医生需要了解他们的风险和建议的监测。
Childhood cancer survivors may develop a second malignant neoplasm during adulthood and therefore require regular surveillance. To examine adherence to population cancer screening guidelines by survivors at average risk of developing a second malignant neoplasm, and to cancer surveillance guidelines by survivors at high risk of developing a second malignant neoplasm. Retrospective cohort study. The Childhood Cancer Survivor Study (CCSS), a 26 center study of long-term survivors of childhood cancer who were diagnosed between 1970 and 1986. 4,329 male and 4,018 female survivors of childhood cancer who completed a CCSS questionnaire assessing screening and surveillance for new cancers. Patient-reported receipt and timing of mammography, Papanicolaou smear, colonoscopy, or skin examination was categorized as adherent to the United States Preventive Services Task Force guidelines for survivors at average risk for breast or cervical cancer, or the Children’s Oncology Group guidelines for survivors at high risk for developing breast, colorectal or skin cancer as a result of their therapy. Among average risk female survivors, 2,743/3,392 (80.9%) reported a Papanicolaou smear within the recommended period, and 140/209 (67.0%) reported a mammogram within the recommended period. Among high risk survivors, rates of recommended mammography among females, and colonoscopy and complete skin exams among both genders were only 241/522 (46.2%), 91/794 (11.5%) and 1,290/4,850 (26.6%), respectively. Data were self report. CCSS participants are a select group of survivors and their compliance may not be representative of all childhood cancer survivors. Female survivors at average risk for developing a second malignant neoplasm demonstrate reasonable rates of screening for cervical and breast cancer. However, surveillance for new cancers is very poor amongst survivors at highest risk for colon, breast or skin cancer, suggesting that survivors and their physicians need education about their risks and the recommended surveillance.
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影响因子：
45.3
作者：
Dores, GM;Metayer, C;Travis, LB
通讯作者：
Travis, LB
影响因子：
8.8
作者：
Jenkinson, HC;Hawkins, MM;Stiller, CA;Winter, DL;Marsden, HB;Stevens, MCG
通讯作者：
Stevens, MCG
影响因子：
39.2
作者：
Henderson TO;Amsterdam A;Bhatia S;Hudson MM;Meadows AT;Neglia JP;Diller LR;Constine LS;Smith RA;Mahoney MC;Morris EA;Montgomery LL;Landier W;Smith SM;Robison LL;Oeffinger KC
通讯作者：
Oeffinger KC
影响因子：
45.3
作者：
Bhatia, S;Yasui, Y;Meadows, AT
通讯作者：
Meadows, AT
影响因子：
45.3
作者：
Landier, W;Bhatia, S;Hudson, MM
通讯作者：
Hudson, MM