The myth of the "vulnerable plaque": transitioning from a focus on individual lesions to atherosclerotic disease burden for coronary artery disease risk assessment.
The myth of the "vulnerable plaque": transitioning from a focus on individual lesions to atherosclerotic disease burden for coronary artery disease risk assessment.
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DOI：
10.1016/j.jacc.2014.11.041
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发表时间：
2015-03-03
影响因子：
24
通讯作者：
Fuster, Valentin
中科院分区：
文献类型：
--
作者：
Arbab-Zadeh, Armin;Fuster, Valentin
The cardiovascular science community has pursued the quest to identify vulnerable atherosclerotic plaque in patients for decades, hoping to prevent acute coronary events. However, despite major advancements in imaging technology that allow visualization of rupture-prone plaques, clinical studies have not demonstrated improved risk prediction compared to traditional approaches. Considering the complex relationship between plaque rupture and acute coronary event risk suggested by pathology studies and confirmed by clinical investigations, these results are not surprising. This review summarizes the evidence supporting a multifaceted hypothesis of the natural history of atherosclerotic plaque rupture. Managing patients at risk of suffering acute coronary events mandates a greater focus on the atherosclerotic disease burden, rather than on features of individual plaques.
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影响因子：
158.5
作者：
DAVIES, MJ;THOMAS, A
通讯作者：
THOMAS, A
影响因子：
158.5
作者：
Detrano, Robert;Guerci, Alan D.;Kronmal, Richard A.
通讯作者：
Kronmal, Richard A.
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ARBUSTINI, E;GRASSO, M;SPECCHIA, G
通讯作者：
SPECCHIA, G
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Falk, Erling
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37.8
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